中国免疫学杂志2024，Vol.40Issue(8)：1590-1594,5.DOI:10.3969/j.issn.1000-484X.2024.08.004
基于病毒样颗粒的癌症疫苗研究进展
Research progress of cancer vaccines based on virus-like particles
摘要
Abstract
Active immunotherapy for cancer aims to treat disease by inducing effective cellular immunity and humoral immunity.Research on virus-like particles(VLPs)vaccines has made tremendous progress in recent years,dramatically reducing morbidity and mortality from some infectious diseases.VLPs are nanoparticles self-assembled from one or more structural proteins,with highly ordered repeat sequences and good immunogenicity,which can induce strong cellular immune and humoral immune responses.VLPs can overcome immunosuppressive state of tumor microenvironment,break self-tolerance,and trigger strong cytotoxic T lymphocyte activity,which is critical for both viral clearance and destruction of cancer cells.This article mainly reviews current research progress of VLPs-based cancer vaccines and potential defects of VLPs as vaccine carriers in development of cancer vaccines.关键词
肿瘤/疫苗/病毒样颗粒Key words
Tumor/Vaccines/Virus-like particles分类
生物科学引用本文复制引用
舒星富,陈遥,马小梅,苏津贤,柏家林,张海霞,马忠仁..基于病毒样颗粒的癌症疫苗研究进展[J].中国免疫学杂志,2024,40(8):1590-1594,5.基金项目
国家自然科学基金(31860696) （31860696）
2020年度甘肃省教育厅高等学校创新基金项目(2020B-066) （2020B-066）
西北民族大学中央高校基本科研业务费资金项目(31920190085). （31920190085）
