中国免疫学杂志2024，Vol.40Issue(8)：1718-1725,中插2,9.DOI:10.3969/j.issn.1000-484X.2024.08.023
多发性硬化铜死亡基因的免疫浸润机制及潜在中药治疗预测
Immune infiltration mechanism of cuproptosis genes in multiple sclerosis and prediction of potential Chinese medicine treatment
蒙毅 1谭文澜 1江颖 1吴月霞 1傅有学 1曹康 1张琼心 1陈晓丽2
作者信息
- 1. 广西中医药大学附属瑞康医院,南宁 530011
- 2. 广西中医药大学,南宁 530001
- 折叠
摘要
Abstract
Objective:To analyze the correlation between cuproptosis genes and immune infiltration during the occurrence and development of multiple sclerosis(MS),and to predict the traditional Chinese medicine,to provide theoretical basis for the mecha-nism study of cuproptosis in MS immune infiltration and Chinese medicine to intervene in immune regulation.Methods:The gout chip of MS was downloaded from the GEO database and standardized;based on the processed data,immune cells and functions were ex-tracted and quantified,and the correlation and differences of immune cells and functions were analyzed;at the same time,cuproptosis genes related to MS were screened out,a risk model was constructed,and enrichment analysis was carried out;the prediction of cu-proptosis genes and immune-related biological processes were carried out.Results:① Among immune cells,T follicular helper cell and B cell showed the strongest positive correlation;among the immune functions,parainflammation and typeⅠIFN reponse showed the strongest positive correlation;②B cell,T helper cell and human leukocyte antigen were lowly expressed in MS patients,while major histocompatibility complex class Ⅰ,parainflammation and typeⅠIFN response were significantly expressed;③ The cupropto-sis genes associated with MS were SLC31A1,PDHA1,NLRP3,MTF1,GLS and DBT,of which DBT was the most likely risk factor for MS;④The occurrence and development of MS involves biological processes such as IL-4 production,T-helper cell differentiation,and acute inflammatory response,which were related to pathways such as arginine biosynthesis,citrate cycle,and propanoate metabo-lism;⑤Banxia,Danshen,Jianghuang and other traditional Chinese medicines may be used as potential molecular drug sources.Con-clusion:The expression of cuproptosis gene is closely related to MS-related immune cells and functions,which can provide support for the basic research of MS.关键词
铜死亡/多发性硬化/免疫浸润/生物信息学/免疫功能Key words
Cuproptosis/Multiple sclerosis/Immune infiltration/Bioinformatics/Immune function分类
医药卫生引用本文复制引用
蒙毅,谭文澜,江颖,吴月霞,傅有学,曹康,张琼心,陈晓丽..多发性硬化铜死亡基因的免疫浸润机制及潜在中药治疗预测[J].中国免疫学杂志,2024,40(8):1718-1725,中插2,9.
