中国免疫学杂志2024，Vol.40Issue(8)：1740-1743,4.DOI:10.3969/j.issn.1000-484X.2024.08.026
嗜酸性粒细胞及嗜酸性粒细胞/淋巴细胞比值预测不同季节儿童过敏性哮喘的意义
Significance of eosinophil and eosinophil/lymphocyte ratio predicting allergic asthma in children with different seasons
步美玲 1刘玲玲 2范卫华 2刘可可 2袁梦 3姜荷云 2冯绛楠 2王金荣2
作者信息
- 1. 山东第一医科大学附属省立医院,济南 250021||山东中医药大学第二临床医学院,济南 250355
- 2. 山东第一医科大学附属省立医院,济南 250021
- 3. 山东中医药大学第二临床医学院,济南 250355
- 折叠
摘要
Abstract
Objective:To explore significance of eosinophil and eosinophil/lymphocyte ratio(ELR)in predicting allergic asth-ma in children in different seasons.Methods:Retrospective analysis of children with asthma who visited pediatric respiratory depart-ment outpatient clinic and ward of Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2021 to December 2021,whose allergen specific IgE(sIgE)and peripheral blood cell analysis were complete.sIgE≥0.35 kUA/L were included in allergic asthma group,sIgE<0.35 kUA/L and total allergen IgE<60 kUA/L were included in non-allergic asthma group.General data and changes in peripheral blood cells of two groups were analyzed.Results:There were 1 378 qualified subjeats,including 999(72.5%)in allergic asthma group and 379(27.5%)in non-allergic asthma group.Number of visits in allergic asthma group varied seasonally,with the most in autumn.Peripheral blood lymphocyte count(LYMPH),eosinophil count(EOS)and ELR were all higher in children with allergic asthma than in children with non-allergic asthma(P<0.05),and platelet/lymphocyte ratio(PLR)was lower than that in children with non-allergic asthma(P<0.05).Peripheral blood LYMPH,PLT,EOS and ELR of children with allergic asthma differed between four seasons,which were higher than those of non-allergic asthma in each season in EOS and ELR,LYMPH was significantly higher than that of children with non-allergic asthma in autumn,and PLT was significantly lower than that of children with non-allergic asthma in spring(P<0.05).EOS predicted AUC of spring,summer,autumn and winter were 0.79,0.77,0.71 and 0.64 in children with allergic asthma,and ELR predicted AUC were 0.72,0.48,0.73 and 0.68 in children with allergic asthma.Conclusion:Allergic asthma in children is seasonally variable and peaks in autumn.EOS and ELR in peripheral blood cells in children with allergic asthma are higher than in children with non-allergic asthma in each season of year,LYMPH is significantly higher than children with non-allergic asthma in the fall,and PLT is lower than in children with non-allergic asthma in spring,suggesting that allergic asthma type Ⅱinflammation persists,and EOS and ELR have predictive value for children's allergic asthma.关键词
过敏性哮喘/嗜酸性粒细胞/嗜酸性粒细胞/淋巴细胞比值/儿童Key words
Allergic asthma/Eosinophils/Eosinophil/lymphocyte ratio/Children分类
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步美玲,刘玲玲,范卫华,刘可可,袁梦,姜荷云,冯绛楠,王金荣..嗜酸性粒细胞及嗜酸性粒细胞/淋巴细胞比值预测不同季节儿童过敏性哮喘的意义[J].中国免疫学杂志,2024,40(8):1740-1743,4.
