中国全科医学2024，Vol.27Issue(35)：4455-4461,7.DOI:10.12114/j.issn.1007-9572.2023.0638
肠道菌群与心力衰竭合并抑郁的研究进展
Advances in Gut Microbiota in Heart Failure Combined with Depression
摘要
Abstract
Heart failure patients are prone to depression,and interact with each other,leading to lower quality of life and poor prognosis of patients.As the largest microecosystem in the human body,changes in the composition,structure and function of the gut microbiota are closely related to the physiological and pathological states of the host.Currently,the"gut-heart/brain axis"has been used to explain the link between gut microbiota,cardiovascular diseases,and mood states,which is an important comorbid basis for heart failure and depression.In this paper,we reviewed the mechanisms of gut microbiota,metabolites,and vagus nerve in the development of heart failure and depression,and propose that mediterranean diet,probiotics,and microbiota transplantation have the potential to improve the"microbiota-gut-heart/brain axis",providing a new perspective for the treatment of heart failure patients comorbid with depression.关键词
心力衰竭/抑郁/肠道菌群/代谢产物/综述Key words
Heart failure/Depression/Gut microbiota/Metabolite/Review分类
医药卫生引用本文复制引用
黄凯,张浥,杨春,杨玲..肠道菌群与心力衰竭合并抑郁的研究进展[J].中国全科医学,2024,27(35):4455-4461,7.基金项目
国家自然科学基金资助项目(82070405) （82070405）
常州市"十四五"卫生健康高层次人才培养工程—领军人才(2022260) （2022260）
常州市医学重点学科:心血管病学(CZXK202202) （CZXK202202）
