中国全科医学2024，Vol.27Issue(35)：4462-4467,6.DOI:10.12114/j.issn.1007-9572.2023.0835
免疫失衡在腹泻型肠易激综合征发病中的机制及中药干预研究进展
Research Progress on the Mechanism of Immune Imbalance in the Pathogenesis of IBS-D and Chinese Medicine Intervention
摘要
Abstract
Diarrhea-predominant irritable bowel syndrome(IBS-D)is a clinically common functional gastrointestinal disease,in which immune imbalance plays an important role.Related immune cells include innate immune cells and adaptive immune cells,and immune cytokines include immunoglobulin,interferon,interleukin,tumor necrosis factor,etc.Traditional Chinese medicine monomers/compounds or compound formulas can regulate immunotherapy for IBS-D through multi-pathway,multi-target.This article systematically reviews and sorts out relevant literature on targeted immunotherapy of IBS-D using traditional Chinese medicine monomers/compounds and compound therapies from the perspectives of immune imbalance and intestinal infection,dysbiosis of flora,brain-gut axis disorder,and endocrine disorders.At the same time,it confirms the similarities between the"spleen as the guard"and immunity,to provide ideas for traditional Chinese medicine to treat IBS-D and related diseases through immune-mediated pathways.关键词
腹泻型肠易激综合征/免疫失衡/中药复方/中药单体/化合物/研究进展Key words
Diarrhea-predominant irritable bowel syndrome/Immune imbalance/Chinese medicine compound/Traditional Chinese medicine monomers/compounds/Research progress分类
医药卫生引用本文复制引用
梅笑,潘海迪,吴晓睿,贺昌辉,窦鑫,邓华亮,王伟..免疫失衡在腹泻型肠易激综合征发病中的机制及中药干预研究进展[J].中国全科医学,2024,27(35):4462-4467,6.基金项目
国家自然科学基金青年基金资助项目(81904128) （81904128）
山东省中医药重点学科中医脾胃病学(鲁卫中医药科教字[2022]4号) （鲁卫中医药科教字[2022]4号）
山东省中医药科技项目(面上项目M-2023167) （面上项目M-2023167）
国家中医药管理局科技司共建科技项目(GZY-KJS-SD-2023-035) （GZY-KJS-SD-2023-035）
