中国全科医学2024，Vol.27Issue(36)：4554-4560,7.DOI:10.12114/j.issn.1007-9572.2024.0187
社区人群心内膜下心肌活力率的影响因素研究
Influencing Factors for Subendocardial Viability Ratio in the Community Population
摘要
Abstract
Background At present,cardiovascular diseases still have a high incidence and mortality worldwide.Subendocardial viability ratio(SEVR)is calculated from the analysis of left ventricular and aortic pressure curves in invasive hemodynamic studies,serving as a valuable indicator of myocardial perfusion,and predictive factor for cardiovascular adverse events and mortality in different populations.Although having certain limitations,non-invasive measurements of SEVR are valuable tools for evaluating myocardial perfusion and assessing cardiovascular risk.However,large-scale epidemiological studies to explore the practical value of SEVR in primary and secondary prevention of cardiovascular diseases are scant.Objective This study aims to non-invasively measure SEVR in a large-scale Beijing community-based population and to identify the influencing factors.Methods It was a cross-sectional follow-up study involving a cohort of residents(≥40 years of age)with atherosclerosis in the Shougang Community,Shijingshan District,Beijing,who were treated in the Department of Cardiology,Peking University First Hospital from December 2011 to April 2012.Non-invasive SEVR measurements were conducted using Pulsepen(DiaTecne srl,San Donato Milanese,Italy)during the follow-up period in 2018.Generalized linear regression models were applied to analyze influencing factors for SEVR.Results A total of 6 568 participants followed up in 2018 were initially enrolled.After excluding those without SEVR data for arrhythmia(2.8%),6 382 eligible ones were finally included in our study.SEVR measurements were obtained from 97.2%of patients.In the cohort,there were 2 130 males and 4 252 females,with a mean SEVR of(144±22)%.The Multivariate linear regression analysis showed that sex(β=-11.00),age(β=-0.53),smoking(β=2.36),hypertension(β=-4.12),dyslipidemia(β=-1.45),diabetes(β=-4.36),antihypertensive drugs(β=3.72),and hypoglycemic treatment(β=-3.71)were independently associated with SEVR(P<0.05).In males,age(β=-0.67),hypertension(β=-3.20),dyslipidemia(β=-2.73),diabetes(β=-3.42),and hypoglycemic treatment(β=-5.07)were independent influencing factors for SEVR(P<0.05).In females,age(β=-0.48),smoking(β=9.44),hypertension(β=-4.98),diabetes(β=-4.95),antihypertensive drugs(β=5.26),and hypoglycemic treatment(β=-2.82)were independent influencing factors for SEVR(P<0.05).Conclusion Non-invasive measurement of SEVR is feasible in large-scale community-based populations.SEVR is associated with traditional risk factors,such as sex,age,smoking,hypertension,dyslipidemia,and diabetes.The relationship between SEVR and medication needs to be explored through further research.关键词
心内膜下心肌活力率/动脉粥样硬化/社区人群/队列研究/影响因素分析Key words
Subendocardial viability ratio/Atherosclerosis/Community population/Cohort study/Root cause analysis分类
医药卫生引用本文复制引用
高澜,张祥凝,谢昊泰,范芳芳,贾佳,李建平,马为,张岩..社区人群心内膜下心肌活力率的影响因素研究[J].中国全科医学,2024,27(36):4554-4560,7.基金项目
国家重点研发计划(2021YFC2500600,2021YFC2500601,2021YFC2500503) （2021YFC2500600,2021YFC2500601,2021YFC2500503）
