中国实用儿科杂志2024，Vol.39Issue(8)：595-602,8.DOI:10.19538/j.ek2024080609
血清抗苗勒管激素和抑制素B在中枢性性早熟和快进展型早发育女童诊断中的价值
Value of serum AMH and INHB in the diagnosis of central precocious puberty and early and fast puberty girls
摘要
Abstract
Objective To investigate the role of serum anti-mullerian hormone(AMH)and inhibin-B(INHB)in(central precocious puberty,CPP)and rapidly-progressive puberty(early and fast puberty,EFP).Methods A total of 423 healthy girls with central precocious puberty,early and fast puberty,premature thelarche or being undeveloped who were treated in the Department of Endocrinology and Genetics and Metabolism of Jiangxi Children's Hospital from October 2020 to December 2022 were retrospectively collected.Clinical data,including age,height,weight,sexual development,levels of sex hormones,AMH,and INHB,and uterine and ovarian volume,were collected.The data of CPP group and non-CPP group(PT group and healthy group)were compared,and the diagnostic value of AMH and INHB in predicting CPP girls was determined by receiver operating characteristic curve(ROC)method.The data of EFP group,CPP group and healthy group were compared using ROC method to determine whether AMH and INHB could be used for early warning of EFP girls,and Spearman correlation analysis was used to analyze the correlation among the indexes.Results The CPP group had higher serum AMH and INHB levels than the PT group,while the EFP group had higher serum INHB levels than the PT group.The area under the ROC curve for INHB in the diagnosis of CPP was 0.815(P＜0.001),with sensitivity and specificity being 83.0％and 62.7％,respectively,while the area under the ROC curve for AMH in the diagnosis of CPP was 0.576(P=0.019).AMH was negatively correlated with levels of FSH,LH peak,and FSH peak.The area under the ROC curve for early warning EFP by INHB was 0.896(P＜0.001),with sensitivity and specificity being 90.7％and 77.6％,respectively.The area under the ROC curve of volume of uterus for early warning EFP was 0.944(P＜0.001),with sensitivity and specificity being 81.4％and 92.3％,respectively.The area under the ROC curve of INHB combined with UV for early warning EFP was 0.964(P＜0.001),with corresponding sensitivity and specificity being 93.8％and 87.4％,respectively.In EFP,INHB was positively correlated with UV,basal LH,basal FSH,and basal LH/basal FSH levels.Conclusion This study confirms the diagnostic value of INHB for CPP girls.This study indicates that AMH levels can be used as a potential indicator to distinguish between CPP and PT.The combination of INHB level with UV detection is significant for early warning EFP girls in clinical practice.关键词
抗苗勒管激素/抑制素B/中枢性性早熟/快进展型早发育/女童Key words
anti-mullerian hormone/inhibin-B/central precocious puberty/early and fast puberty/girls分类
医药卫生引用本文复制引用
杨玉,张海萌,黄慧,杨利,谢理玲,张东光..血清抗苗勒管激素和抑制素B在中枢性性早熟和快进展型早发育女童诊断中的价值[J].中国实用儿科杂志,2024,39(8):595-602,8.基金项目
江西省卫生健康委员会重大课题(2023ZD007) （2023ZD007）
