中国实用妇科与产科杂志2024，Vol.40Issue(8)：845-848,4.DOI:10.19538/j.fk2024080115
SMARCA4缺失性未分化子宫肉瘤1例报告并文献复习
SSMARCA4-deficient undifferentiated uterine sarcoma:one case report and review of the literature
摘要
Abstract
Objective To investigate the clinicopathological features,diagnosis,treatment and prognosis of SMARCA4-deficient undifferentiated uterine sarcoma.Methods A case of SMARCA4-deficient undifferentiated uterine sarcoma at the Tenth Affiliated Hospital of Southern Medical University on November 20,2023 was analyzed retrospectively.A sys-tematic search was performed to identify articles investigating SMARCA4-deficient undifferentiated uterine sarcoma from PubMed,Medline,CNKI and Chinese biomedical literature database,and the related literatures were analyzed and summarized.Results A 30-year-old patient came to our hospital with uterine mass for more than 3 months.She under-went total hysterectomy and bilateral salpingectomy.Postoperative pathology confirmed the diagnosis of SMARCA4-defi-cient undifferentiated uterine sarcoma.To date only 35 cases of SMARCA4-deficient undifferentiated uterine sarcoma have been reported worldwide.The age of patients ranged from 24 to 70(43.03±11.97)years.Most of them presented with vaginal bleeding.Treatment methods were recorded in 23 cases,21 of them underwent total hysterectomy and bilat-eral salpingo-oophorectomy.Follow-up was available for 15,of whom 11 died and with the median survival time was on-ly 6 months.Conclusion SMARCA4-deficient undifferentiated uterine sarcoma is a newly recognized aggressive sub-type of uterine sarcoma with high malignancy,and should be paid more attention to during clinical practice.关键词
SMARCA4缺失/子宫肉瘤/临床病理特征/治疗/预后Key words
SMARCA4-deficient/uterine sarcoma/clinicopathological features/treatment/prognosis分类
医药卫生引用本文复制引用
卢碧燕,朱莹,禤文婷,罗海波,黄素然,李仲均..SMARCA4缺失性未分化子宫肉瘤1例报告并文献复习[J].中国实用妇科与产科杂志,2024,40(8):845-848,4.基金项目
国家自然科学基金(82103269) （82103269）
广东省科技厅粤莞联合基金(2022A1515140168) （2022A1515140168）
广东省医学科研基金(C2023114、C2022125) （C2023114、C2022125）
东莞市社会科技重点项目(20231800935872) （20231800935872）
东莞松山湖大科学装置散裂中子源开放课题(KFKT2022BO1) （KFKT2022BO1）
