慢性胰腺炎干细胞治疗研究进展OA北大核心CSTPCD

Chronic pancreatitis(CP)has a complex pathogenesis and still lacks a targeted and effective treatment.Stem cells have the ability to regulate inflammation and immune response,and promote repair and regeneration of damaged tissues,which have been applied in many organs or tissues.ln recent years,stem cell therapy has received increasing attention in CP,and studies have demonstrated its role in anti-inflammation and anti-fibrosis.However,there is still a lack of research on the treatment of painful symptoms of CP and complications such as diabetes mellitus and pancreatic exocrine insufficiency.Currently,stem cell research in CP is only at the cellular and animal level,and no clinical trials have yet been performed.This paper summarizes the research progress of stem cell therapy in CP in pancreatic inflammation and fibrosis,abdominal pain,pancreatic exocrine insufficiency,and diabetes mellitus.