中国实用内科杂志2024，Vol.44Issue(7)：585-590,6.DOI:10.19538/j.nk2024070113
不明原因与常见类型获得性维生素K依赖凝血因子缺乏症临床对照研究
Clinical controlled study on unexplained and common types of acquired vitamin K-dependent coagulation factors deficiency
摘要
Abstract
Objective The clinical and test characteristics,treatment methods,prognosis,and possible etiology of patients with unexplained acquired deficiency of vitamin K-dependent coagulation factors(ADVKDCF)were analyzed to improve the understanding and treatmentin the patients.Methods The clinical features,laboratory test results and treatment methods of 21 patients withunexplained ADVKDCF and 26 patients with common ADVKDCF in the Second Xiangya Hospital of Central South University from March 2019 to March 2021 were retrospctively studied,and their prognosis were tracked.Results ADVKDCF can be preliminatively determined by prothrombin time being earlier and longer than partially activated prothrombin time in patients with unexplained ADVKDCF who come to hospital due to bleeding symptoms.Then,ADVKDCF can be confirmed by vitamin K-dependent coagulation factors activity detection or vitamin K therapeutic diagnosis finally.In addition,fibrinogen and hepatic function were normal.Vitamin K supplement was the main treatment,and the clinical characteristics and prognosisof patients with unexplained ADVKDCF were like those of ADVKDCF patients caused by rodenticide poisoning.Conclusion Unexplained ADVKDCF should consider the possibility of rodenticide poisoning,and vitamin K should be supplemented in time,in sufficient amount and for sufficient duration.关键词
维生素K依赖凝血因子/灭鼠药/维生素K/凝血酶原时间/Ⅶ因子Key words
vitamin K-dependent coagulation factors/rodenticide/vitamin K/prothrombin time/factor Ⅶ分类
医药卫生引用本文复制引用
罗玉娇,张广森,田卫平,王业伟,李吉..不明原因与常见类型获得性维生素K依赖凝血因子缺乏症临床对照研究[J].中国实用内科杂志,2024,44(7):585-590,6.基金项目
湖南省自然科学基金(2022JJ30850,2024JJ9223) （2022JJ30850,2024JJ9223）
