中国实用内科杂志2024，Vol.44Issue(8)：665-669,5.DOI:10.19538/j.nk2024080112
女性2型糖尿病患者绝经后多种甲状腺参数与糖尿病肾脏疾病的关系
Association between multiple thyroid parameters and diabetic kidney disease in post-menopausal women with type 2 diabetes
摘要
Abstract
Objective To analyze the association of thyroid parameters with kidney disorders in post-menopausal women with type 2 from diabetes.Methods We conducted a retrospective study among 365 post-menopausal women with type 2 diabetes from January 2016 to December 2021 in the second affiliated hospital of Anhui medical unirersity and collected the data of personal history,personal lifestyles,physical measurment and laboratory indicators.SPINA-GD,SPINA-GT,TSHI,TT4RI,were calculated.The association between thyroid parameters and DKD was analyzed using logistic regression models.Results Free triiodothyronine(FT3)was positively correlated with eGFR and negatively correlated with creatinine,P＜0.05.SPINA-GD and SPINA-GT were positively correlated with eGFR and negatively correlated with UACR and Cr,P＜0.05.TSHI and TT4RI were positively correlated with UACR and Cr and negatively correlated with eGFR,P＜0.05.Thyroid-stimulating hormone(TSH)was positively correlated with UACR and negatively correlated with eGFR,P＜0.05.After adjusting for confounding factors,logistic regression analysis showed that SPINA-GD(OR 0.88,95％CI:0.82-0.96)was a protective factor of DKD.Conclusion Higher SPINA-GD can reduce the risk of DKD in postmenopausal womens with type 2 diabetes.关键词
绝经后女性/甲状腺功能/甲状腺激素敏感性/糖尿病肾脏疾病Key words
postmenopausal women/thyroid function/sensitivity to thyroid hormones/diabetic kidney disease分类
医药卫生引用本文复制引用
刘妮娜,潘天荣,钟兴,杜益君..女性2型糖尿病患者绝经后多种甲状腺参数与糖尿病肾脏疾病的关系[J].中国实用内科杂志,2024,44(8):665-669,5.基金项目
安徽省高校自然科学研究项目(KJ2021A0319) （KJ2021A0319）
安徽医科大学第二附属医院首批临床研究培育计划(2020LCYB08) （2020LCYB08）
慢病防控联合研究基金(MBLHJJ202005) （MBLHJJ202005）
