二甲双胍与替加环素协同抑制TMexCD1-TOprJ1阳性肺炎克雷伯菌的机制OA北大核心
Mechanism of Synergistic Inhibition of TMexCD1-TOprJ1 Positive Klebsiella pneumoniae by Metformin and Tigecycline
为探究二甲双胍联合替加环素对TMexCD1-TOprJ1外排泵介导的替加环素耐药肺炎克雷伯菌的抗菌效果和作用机制.本试验采用棋盘肉汤法和时间杀菌曲线评价二甲双胍与替加环素联用对肺炎克雷伯菌的体外抑菌效果,并通过测定外排泵功能(罗丹明B外排试验和替加环素蓄积试验)、质子驱动力(PMF)、细胞外膜通透性和生物被膜形成能力探究二甲双胍与替加环素联合杀菌机制.结果显示,二甲双胍与替加环素联合使用对TMexCD1-TOprJ1阳性菌株的部分抑菌浓度指数(F…查看全部>>
This study aims to investigate the antibacterial effect and mechanism of metformin combined with tigecycline on TMexCD1-TOprJ1 efflux pump-mediated tigecycline-resistant Klebsiella pneumoniae.The checkerboard broth microdilution method and time-kill curve assay were used to evaluate the in vitro antibacterial effect of metformin combined with tigecycline against Klebsiella pneumoniae.The mechanism of combined bactericidal action was explored by measuring eff…查看全部>>
刘挺;孙乃岩;黄金虎;王丽平;王晓明
南京农业大学动物医学院,江苏南京 210095南京农业大学动物医学院,江苏南京 210095南京农业大学动物医学院,江苏南京 210095南京农业大学动物医学院,江苏南京 210095南京农业大学动物医学院,江苏南京 210095
畜牧业
二甲双胍替加环素TMexCD1-TOprJ1肺炎克雷伯菌联合用药
metformintigecyclineTMexCD1-TOprJ1Klebsiella pneumoniaecombined medication
《中国兽医杂志》 2024 (8)
1-9,9
江苏省重点研发计划(BE2023332)
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