中国现代医学杂志2024，Vol.34Issue(16)：11-16,6.DOI:10.3969/j.issn.1005-8982.2024.16.003
妊娠期糖尿病患者血清microRNA-122联合microRNA-7047-5p预测不良围生儿结局价值
The value of serum microRNA-122 combined with microRNA-7047-5p in predicting adverse perinatal outcomes in patients with gestational diabetes mellitus
摘要
Abstract
Objective To explore the value of serum microRNA-122(miR-122)combined with microRNA-7047-5p(miR-7047-5p)in predicting adverse perinatal outcomes in patients with gestational diabetes mellitus(GDM).Methods The study included 100 GDM patients admitted to Bozhou People's Hospital from April 2018 to April 2023 as the observation group.Meanwhile,90 healthy pregnant women undergoing routine prenatal care checkups during the same period were selected as the control group.The levels of blood glucose and serum miR-122 and miR-7047-5p were measured in both groups.Pearson correlation analysis was performed to determine the correlation between serum levels of miR-122 and miR-7047-5p and the level of blood glucose.Based on follow-up results of perinatal outcomes,the observation group was further classified into good(85 cases)and poor(15 cases)groups.Serum levels of miR-122 and miR-7047-5p were compared between the two subgroups.The receiver operating characteristic(ROC)curves were constructed to assess the value of serum miR-122 combined with miR-7047-5p in predicting adverse perinatal outcomes in GDM patients.Results The levels of fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPG),and glycosylated hemoglobin(HbAlc)in the observation group were higher than those in the control group(P＜0.05).The relative expression of serum miR-122 was higher(P＜0.05),and that of miR-7047-5p was lower in the observation group compared with the control group(P＜0.05).The Pearson correlation analysis showed that the level of miR-122 was positively correlated with levels of FBG,2 hPG,and HbAlc(r=0.167,0.228 and 0.255,P＜0.05),while the level of miR-7047-5p was negatively correlated with levels of FBG,2 hPG,and HbAlc(r=-0.358,-0.408 and-0.386,P＜0.05).In the poor group,the relative expression of miR-122 was higher(P＜0.05)and that of miR-7047-5p was lower than in the good group(P＜0.05).ROC curve analysis revealed that the combined detection of serum miR-122 and miR-7047-5p for predicting adverse perinatal outcomes in GDM patients yielded a sensitivity of 73.3％(95％CI:44.9％,92.2％)and a specificity of 85.9％(95％CI:76.6％,92.5％),with an area under the curve(AUC)of 0.836(95％CI:0.720,0.952).Conclusions In GDM patients,serum levels of miR-122 and miR-7047-5p are associated with the levels of blood glucose.Besides,the combined detection of these two miRNAs effectively predicts adverse perinatal outcomes in GDM patients,with high predictive sensitivity and specificity.关键词
妊娠期糖尿病/微小核糖核酸-122/微小核糖核酸-7047-5p/血糖/围生儿结局Key words
gestational diabetes mellitus/miR-122/miR-7047-5p/blood glucose/perinatal outcome分类
医药卫生引用本文复制引用
任倩倩,陈东颖,于康军..妊娠期糖尿病患者血清microRNA-122联合microRNA-7047-5p预测不良围生儿结局价值[J].中国现代医学杂志,2024,34(16):11-16,6.基金项目
安徽省高等学校学科研究项目(No:2022AH050688) （No:2022AH050688）
