中国现代医学杂志2024，Vol.34Issue(16)：33-38,6.DOI:10.3969/j.issn.1005-8982.2024.16.006
线粒体相关内质网膜在非酒精性脂肪肝病中的作用及研究进展
Role of mitochondria-associated endoplasmic reticulum membranes in pathogenesis of non-alcoholic fatty liver disease
摘要
Abstract
Non-alcoholic fatty liver disease(NAFLD)is the most prevalent chronic liver disease worldwide.Its disease spectrum ranges from liver steatosis to non-alcoholic steatohepatitis,which may ultimately progress to liver cirrhosis and hepatocellular carcinoma.Mitochondria-associated endoplasmic reticulum membranes(MAMs)are structures where the mitochondria and the endoplasmic reticulum(ER)are in close contact,and play vital roles in different cellular processes,such as calcium homeostasis,mitochondrial homeostasis,apoptosis,autophagy,and lipid metabolism.These processes are deeply involved in the onset and progression of NAFLD,and are crucial in multiple processes in hepatocytes including lipid accumulation,inflammation,apoptosis and fibrosis.Therefore,MAMs are increasingly emerging as a potential therapeutic target for NAFLD.In this review,we summarized the roles of MAMs and cellular functions regulated by MAMs in the pathogenesis of NAFLD.关键词
非酒精性脂肪性肝病/线粒体相关内质网膜/线粒体/内质网/氧化应激/衰老/自噬Key words
non-alcoholic fatty liver disease/mitochondria-associated endoplasmic reticulum membrane/mitochondria/endoplasmic reticulum/oxidative stress/senescence/autophagy分类
医药卫生引用本文复制引用
王心怡,张涛,王继亮..线粒体相关内质网膜在非酒精性脂肪肝病中的作用及研究进展[J].中国现代医学杂志,2024,34(16):33-38,6.基金项目
国家自然科学基金(No:82070647,No:82200972) （No:82070647,No:82200972）
