胍基乙酸对育肥猪生长性能、血清生化指标、抗氧化能力和免疫功能的影响OA北大核心CSTPCD

[Objective]The aim of this study was to explore the effects of dietary supplementation with guanidinoacetic acid on the growth performance,serum biochemical indices,antioxidant capacity and immune function of finishing pigs,and provide reference for the application of guanidinoacetic acid in pig breeding industry.[Method]Thirty-six healthy Duroc × Landrace × Yorkshire three-way crossbred sows with similar body weights were randomly divided into 3 groups with 6 replicates per group and 2 sows per replicate.Finishing pigs in control group were fed basal diet,and finishing pigs in experiment group were supplemented with 0.1％guanidinoacetic acid(GAA group)and 0.1％guanidinoacetic acid+0.04％betaine(GAA+BT group)in basal diet,respectively.The experiment lasted for 50 d.At the end of the experiment,finishing pigs were weighed on empty stomachs in replicates and calculated for growth performance,one pig was selected from each replicate for vena cava blood sampling to determine serum biochemical indices,antioxidant capacity and immune function.[Result]① Dietary supplementation with guanidinoacetic acid had no significant effect on growth performance of finishing pigs(P＞0.05).② Compared with control group,the contents of total protein,globulin,interleukin-2,interleukin-10,interferon-γ and immunoglobulin A in serum of finishing pigs in GAA and GAA+BT groups were significantly increased,and the immunoglobulin G content in serum of finishing pigs in GAA group was significantly increased(P＜0.05).The levels of creatinine,uric acid and lactate dehydrogenase in serum of finishing pigs in GAA and GAA+BT groups were significantly decreased,and the malondialdehyde content in serum of finishing pigs in GAA+BT group was significantly decreased(P＜0.05).③ Compared with control and GAA groups,the total antioxidant capacity in serum of finishing pigs in GAA+BT group was significantly increased(P＜0.05).@Compared with control and GAA+BT groups,the tumor necrosis factor-α content in serum of finishing pigs in GAA group was significantly increased(P＜0.05).[Conclusion]Dietary supplementation with guanidinoacetic acid did not affect the growth performance of finishing pigs,however,it could improve the metabolism level,enhance the antioxidant capacity and immune function of finishing pigs,and it was effective both alone and in combination with the addition of betaine.