中国药科大学学报2024，Vol.55Issue(4)：463-471,9.DOI:10.11665/j.issn.1000-5048.2024042901
酶法合成黄酮类碳苷化合物研究进展
Recent progress of enzymatic synthesis of flavonoid C-glycosides with C-glycosyltransferase
摘要
Abstract
C-Glycosylation is one of the modifications of plant secondary metabolites,which can increase the stability,bioavailability,water solubility and biological activities.Flavonoid C-glycosides,as one of the most important plant secondary metabolites,exhibit important biological activities in regulating plant growth and development,resisting pests and diseases,resisting ultraviolet radiation,and antibacterial etc.Generally,this kind of such compounds are biosynthesized by flavonoids reacting with UDP-Glucose and other nucleoside diphosphates catalyzed by C-glycosyltransferase(CGT).This paper reviews the literature reports on the biosynthesis of flavonoid C-glycosides catalyzed by CGT in recent years,and discusses three strategies for its biosynthesis from the perspectives of raw material flavonoids,flavonoid O-glycosides and flavonoid biosynthetic pathways.Among them,the direct or indirect synthesis of flavonoid C-glycosides using flavonoids as raw materials is the most common synthesis strategy,and the classification,plant origin and catalytic function of various CGTs reported recently were also summarized.关键词
酶法合成/黄酮类碳苷/C-糖基转移酶Key words
enzymatic synthesis/flavonoid C-glycoside/C-glycosyltransferase分类
生物科学引用本文复制引用
叶称连,陈进聪,刘称福..酶法合成黄酮类碳苷化合物研究进展[J].中国药科大学学报,2024,55(4):463-471,9.基金项目
This study was supported by the National Natural Science Foundation of China(No.21762004)and the Science and Technology Project of Jiangxi Provincial Health Commission(No.202310240) 国家自然科学基金项目(No.21762004) （No.21762004）
江西省卫生健康委科技计划项目(No.202310240) （No.202310240）
