中国药科大学学报2024，Vol.55Issue(4)：548-556,9.DOI:10.11665/j.issn.1000-5048.2023111404
纳米晶体药物在不同给药系统中的研究进展
Research progress of nanocrystalline drugs in different drug delivery systems
郝耀廷 1李彦辉 2张慧聪 2刘敬文 2李春雷3
作者信息
- 1. 河北医科大学药学院,石家庄 050031
- 2. 石药集团中奇制药技术(石家庄)有限公司,石家庄 050000
- 3. 河北医科大学药学院,石家庄 050031||石药集团中奇制药技术(石家庄)有限公司,石家庄 050000
- 折叠
摘要
Abstract
Nanocrystal technology changes the solubility and dissolution rate of insoluble drugs by reducing the particle size to the nanometer level.This technology is not limited by carrier materials and encapsulation rate.It is suitable for a variety of drug delivery routes and easy for industrial production.It has gradually become a cutting-edge hot technology in the international pharmaceutical field to improve the absorption of insoluble drugs and improve their bioavailability.This article introduces the influencing factors and challenges of nanocrystal drugs(NC)in parenteral,ocular,transdermal and pulmonary administration,and focuses on nanocrystal drugs that have been marketed or are still in the preclinical or clinical trial stages of these delivery systems,in order to provide some insight for the further development of poorly soluble drug nanocrystal preparations.关键词
纳米晶体/给药途径/稳定剂/药动学/生物利用度Key words
nanocrystal/route of administration/stabilizer/pharmacokinetics/bioavailability分类
医药卫生引用本文复制引用
郝耀廷,李彦辉,张慧聪,刘敬文,李春雷..纳米晶体药物在不同给药系统中的研究进展[J].中国药科大学学报,2024,55(4):548-556,9.
