术后通气方对术后肠麻痹小鼠肠道损伤的改善作用及机制OA北大核心CSTPCD
Improvement effect and mechanism of Shuhou tongqi formula on intestinal injury in mice with postoperative ileus
目的 研究术后通气方对术后肠麻痹(POI)小鼠肠道损伤的改善作用及机制.方法 将小鼠随机分为假手术组、模型组、阳性对照组(枸橼酸莫沙必利片,1.95 mg/kg)、术后通气方组(1.88 g/kg),每组6只.除假手术组外,其余各组小鼠使用经典小肠干扰术制备POI模型.各组小鼠灌胃相应药液/水,每天1次,连续2 d.末次给药后,检测小鼠肠道炭末推进率;观察小鼠回肠组织病理形态学变化;检测小鼠血清中白细胞介素6(IL-6)、IL-10、肿瘤坏死因子…查看全部>>
OBJECTIVE To study the improvement effect and mechanism of Shuhou tongqi formula on intestinal injury in mice with postoperative ileus(POI).METHODS Mice were randomly divided into sham operation group,model group,positive control group(Mosapride citrate tablets,1.95 mg/kg),and Shuhou tongqi formula group(1.88 g/kg),with 6 mice in each group.Except for the sham operation group,POI model was induced in other groups by typical small intestinal interference.Each…查看全部>>
卢雨暄;江志伟;谢怡君;王弈竹;哈静文;束雅春
南京中医药大学附属医院药学部,南京 210029南京中医药大学附属医院药学部,南京 210029南京中医药大学附属医院药学部,南京 210029中国药科大学中药学院,南京 211112中国药科大学中药学院,南京 211112南京中医药大学附属医院药学部,南京 210029
药学
术后通气方术后肠麻痹肠道损伤炎症因子肠道菌群
Shuhou tongqi formulapostoperative ileusintestinal injuryinflammatory factorintestinal flora
《中国药房》 2024 (17)
2108-2113,6
江苏省知识产权高价值专利培育计划项目(No.GJ20231160_01)南京市医疗机构中药传统制剂研究立项项目(No.NJCC-ZJ-202303)南京市知识产权项目
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