中国药房2024，Vol.35Issue(17)：2181-2187,7.DOI:10.6039/j.issn.1001-0408.2024.17.22
中药调控NF-κB信号通路改善多囊卵巢综合征的研究进展
Research progress on traditional Chinese medicine improving polycystic ovary syndrome by regulating NF-κB signaling pathway
摘要
Abstract
Polycystic ovary syndrome(PCOS)is a common endocrine disorder among women of childbearing age.Persistent chronic inflammation can promote the progression of PCOS,thereby causing serious impacts on women's endocrine metabolism,reproductive function,and psychological status.Nuclear factors-κB(NF-κB)signaling pathway is one of the most classic inflammatory response transduction pathways and is closely related to the pathological process of PCOS.This article summarizes the mechanism of traditional Chinese medicine intervention in PCOS based on the NF-κB signaling pathway,and finds that various monomers of traditional Chinese medicine[flavonoids(naringenin,soy isoflavone,rhamnocitrin,etc.),alkaloids(berberine,ligustrazine)and terpenoids(artesunate,cryptotanshinone),glycosides(salidroside,glycyrrhizic acid)]and traditional Chinese medicine compounds[formula for tonifying kidney(Bushen huayu formula,Bushen huatan formula,etc.),formula for eliminating damp and dissolving phlegm(Cangfu daotan decoction,Xiehe yin,Erchen decoction),formula for regulating blood circulation and removing stasis(Gexia zhuyu decoction,Huatan tongmai yin)]can alleviate inflammatory response,improve abnormal glucose and lipid metabolism,and enhance ovarian function by inhibiting NF-κB signaling pathway,thus improving PCOS.关键词
多囊卵巢综合征/NF-κB信号通路/中药/炎症Key words
polycystic ovary syndrome/NF-κB signaling pathway/traditional Chinese medicine/inflammation分类
医药卫生引用本文复制引用
张逸,陈萍,吴悦靓,薛苗苗,孙建华..中药调控NF-κB信号通路改善多囊卵巢综合征的研究进展[J].中国药房,2024,35(17):2181-2187,7.基金项目
2024年度河南省中医药科学研究专项(No.2024ZY3006) （No.2024ZY3006）
河南省中医药传承与创新人才工程(仲景工程)中医药青苗人才培养项目(No.豫卫中医函[2021]16号) （仲景工程）
河南中医药大学博士科研启动基金项目(No.RSBSJJ2019-29) （No.RSBSJJ2019-29）
