中国药理学通报2024，Vol.40Issue(9)：1607-1611,5.DOI:10.12360/CPB202309058
钾离子通道在抑郁症治疗中的研究进展
Research progress on therapeutic potentials of potassium channels against depression
摘要
Abstract
Depression is a common mental disorder with an in-creasing incidence rate worldwide,which seriously endangers people's physical and mental health.Currently available antide-pressants focus on increasing the concentration of monoamine transmitters such as 5-hydroxytryptamine,norepinephrine and dopamine in brain,but most of them have low response rates and serious adverse effects.Hence,the treatment of depression re-mains as an unmet clinic need.In recent years,mounting pre-clinical studies and clinical trials suggest that potassium ion channels openers or antagonists have great potential in the treat-ment of depression.In this review the research progress on the therapeutic potentials of voltage-gated potassium channels and two-pore domain potassium channels against depression is sum-marized,which may provide new ideas for the development of novel antidepressants.关键词
抑郁症/钾离子通道/电压门控钾离子通道/双孔钾离子通道/抗抑郁作用/钾离子通道开放剂Key words
depression/potassium channel/voltage-gated po-tassium channel/two-pore domain potassium channel/antide-pressant effect/potassium channel opener分类
医药卫生引用本文复制引用
刘淑娴,张桂森,庄涛..钾离子通道在抑郁症治疗中的研究进展[J].中国药理学通报,2024,40(9):1607-1611,5.基金项目
国家自然科学基金资助项目(No 82304275) （No 82304275）
江苏省优势学科"海洋科学"创新子课题(No 2022JSPAPD006) （No 2022JSPAPD006）
江苏省高等学校自然科学研究项目(No 23KJB350002) （No 23KJB350002）
江苏省海洋药物活性分子筛选重点实验室开放基金项目(No HY202207) （No HY202207）
江苏海洋大学人才引进科研基金项目(No KQ22025) （No KQ22025）
江苏省研究生科研与实践创新计划项目(No KYCX2023-41) （No KYCX2023-41）
