中国药理学通报2024，Vol.40Issue(9)：1616-1621,6.DOI:10.12360/CPB202305071
中药有效成分对银屑病角质形成细胞凋亡的调控作用及机制的研究进展
Research progress on regulation and mechanism of active components of traditional Chinese medicine on keratinocyte apoptosis in psoriasis
摘要
Abstract
Apoptosis is a process of programmed cell death,which has the function of maintaining skin balance.In psoriasis,the disturbance of apoptosis is characterized by abnormal prolif-eration of keratinocytes.Traditional Chinese medicine(TCM)has a regulatory effect on keratinocyte apoptosis,which can in-hibit the excessive proliferation of psoriasis epidermis,promote normal epidermal differentiation,and maintain epidermal homeo-stasis.It has the advantages of fewer adverse reactions and multi-targets.Therefore,this article summarizes and analyzes the specific mechanism of various active ingredients of TCM to in-duce the apoptosis of psoriasis keratinocytes by interfering with related factors and signaling pathways,hoping to provide a refer-ence for the treatment of psoriasis with TCM.关键词
角质形成细胞/细胞凋亡/银屑病/中药有效成分/作用机制/研究进展Key words
keratinocytes/apoptosis/psoriasis/active compo-nents of traditional Chinese medicine/mechanism/research pro-gress分类
医药卫生引用本文复制引用
曹爽,安月鹏,刘树民,杨素清..中药有效成分对银屑病角质形成细胞凋亡的调控作用及机制的研究进展[J].中国药理学通报,2024,40(9):1616-1621,6.基金项目
国家自然科学基金面上项目(No 81973846) （No 81973846）
