中国药理学通报2024，Vol.40Issue(9)：1622-1627,6.DOI:10.12360/CPB202305083
氯胺酮抗抑郁作用的神经生物学机制研究进展
Research progress on neurobiological mechanisms underlying antidepressant effect of ketamine
摘要
Abstract
Major depressive disorder(MDD)is a prevalent con-dition associated with substantial impairment and low remission rates.Traditional antidepressants demonstrate delayed effects,low cure rate,and inadequate therapeutic effectiveness for man-aging treatment-resistant depression(TRD).Several studies have shown that ketamine,a non-selective N-methyl-D-aspartate receptor(NMDAR)antagonist,can produce rapid and sustained antidepressant effects.Ketamine has demonstrated efficacy for reducing suicidality in TRD patients.However,the pharmaco-logical mechanism for ketamine's antidepressant effects remains incompletely understood.Previous research suggests that the an-tidepressant effects of ketamine may involve the monoaminergic,glutamatergic and dopaminergic systems.This paper provides an overview of the pharmacological mechanism for ketamine's anti-depressant effects and discuss the potential directions for future research.关键词
氯胺酮/抑郁症/抗抑郁/单胺能系统/谷氨酸能系统/多巴胺能系统Key words
ketamine/depression/antidepressant/monoamin-ergic system/glutamatergic system/dopaminergic systems分类
医药卫生引用本文复制引用
周冬雨,章文欣,翟晓静,陈丹丹,韩奕,季然,潘晓媛,曹君利,张红星..氯胺酮抗抑郁作用的神经生物学机制研究进展[J].中国药理学通报,2024,40(9):1622-1627,6.基金项目
国家自然科学基金资助项目(No 31970937,82271255) （No 31970937,82271255）
江苏省研究生科研创新计划资助项目(No KYCX21_2713) （No KYCX21_2713）
