中国药理学通报2024，Vol.40Issue(9)：1628-1633,6.DOI:10.12360/CPB202307030
外泌体与阿尔茨海默病研究进展
Advances in exosomes and Alzheimer's disease
摘要
Abstract
Exosomes represent a class of nanoscale extracellular vesicles that facilitate the exchange of genetic information among various cells.Alzheimer's disease(AD)stands as a progressive neurodegenerative disorder characterized by its subtle and advan-cing onset,representing the foremost form of dementia lacking effective therapeutic interventions.Notably,investigations have illuminated the involvement of exosomes in the pathogenesis of AD,attributing diagnostic and therapeutic significance to their role,particularly concerning exosomal microRNAs(miRNA).The miRNAs carried by exosomes serve as potential biomarkers for AD,while also exhibiting potential benefits in ameliorating cognitive dysfunction in individuals afflicted by AD.This article aims to comprehensively review the origins of exosomes(encom-passing both mesenchymal cell-derived exosomes and brain-de-rived exosomes)and their potential as therapeutic agents targe-ting AD.关键词
阿尔茨海默病/外泌体/外泌体类型/药物/miRNA/细胞外囊泡Key words
Alzheimer's disease/exosomes/exosomal type/drugs/miRNA/extracellular vesicles分类
基础医学引用本文复制引用
梁金萍,祝雨辰,刘莎莎,孙洋,邝柏宇,楚世峰,陈乃宏,艾启迪,杨岩涛..外泌体与阿尔茨海默病研究进展[J].中国药理学通报,2024,40(9):1628-1633,6.基金项目
国家自然科学基金资助项目(No U2202214) （No U2202214）
湖南省自然科学基金资助项目(No 2021JJ30512,2023JJ60471) （No 2021JJ30512,2023JJ60471）
湖南省科技厅优秀青年项目(No 21B0354) （No 21B0354）
长沙市妇幼保健院2023年度院级科研重点项目(No 202329-2) （No 202329-2）
