中国药理学通报2024，Vol.40Issue(9)：1649-1657,9.DOI:10.12360/CPB202312038
基于脂质组学的桃红四物汤治疗子宫异常出血的机制研究
Mechanism study on treatment of abnormal uterine bleeding by Taohong Siwu Tang based on lipidomics
摘要
Abstract
Aim To study the effects of Taohong Siwu Tang(TSD)on serum lipid metabolites in rats with abnormal uterine bleeding(AUB),and to analyze the mechanism of action of TSD in improving lipid metabo-lism disorders in AUB.Methods The rat model of AUB was replicated by the method of incomplete abor-tion with drugs,and the lipid metabolites of serum were detected by applying UPLC-Q-Exactive Orbitrap/MS technology,and combined with the principal com-ponent analysis and orthogonal partial least squares-discriminant analysis to screen for differential lipids,the changes of lipids in serum before and after the in-tervention of TSD were clarified.Results A total of 11 differential lipids were screened,mainly phosphati-dyl inositol,phosphatidic acid,phosphatidyl ethanola-mine,phosphatidyl serine,sterol lipids,ceramide,acrylolipids and fatty acids.The screened differential lipids all tended to regress to normal after the adminis-tration of TSD intervention.Conclusion Improvement of AUB by TSD may be related to lipid metabolism such as phosphatidic acid,phosphatidyl inositol,phos-phatidyl ethanolamine,phosphatidyl serine,and ce-ramide.关键词
脂质组学/桃红四物汤/子宫异常出血/差异脂质代谢物/UPLC-Q-Exactive Orbitrap/MS/脂代谢紊乱Key words
lipidomics/Taohong Siwu Tang/abnor-mal uterine bleeding/differential lipid metabolites/UPLC-Q-Exactive Orbitrap/MS/dyslipidemia分类
医药卫生引用本文复制引用
苏梦宇,张艳艳,黄荣,程瑶,钱珊珊,彭灿,彭代银,刘晓闯..基于脂质组学的桃红四物汤治疗子宫异常出血的机制研究[J].中国药理学通报,2024,40(9):1649-1657,9.基金项目
国家自然科学基金资助项目(No 82104513) （No 82104513）
安徽省高校科研项目(No 2023AH050743) （No 2023AH050743）
