新型冠状病毒感染与宿主糖酵解相互作用研究进展OA北大核心CSTPCD
Research progress in interactions between SARS-CoV-2 infection and host glycolysis
糖酵解与病毒感染性疾病关系密切,且病毒和宿主糖酵解之间的相互作用是多种病毒中存在的共性机制.因此,糖酵解调控可能是重要的抗病毒策略.新型冠状病毒(SARS-CoV-2)感染的流行给人类带来了巨大的灾难,需要从更多不同角度去探寻有效的解决方案.SARS-CoV-2可诱导宿主糖酵解水平升高,而宿主糖酵解水平在SARS-CoV-2复制和感染中起重要作用,且与病程进展和多种临床症状及并发症相关.对宿主糖酵解与SARS-CoV-2感染相互作用的研究有助于阐明SARS-CoV-2致病机制并促进相关药物研发.本文对SARS-CoV-2感染与宿主糖酵解之间的相互作用进行综述,以期为从代谢调控角度阐明病毒感染与疾病的关系及研究应对措施提供新视角.
The relationship between glycolysis and viral infectious diseases is close,and the inter-action between viral and host glycolysis is a common mechanism found in a wide range of viruses.Therefore,the regulation of glycolysis may be an important antiviral strategy.The coronavirus diseases 2019 pandemic has brought about a tremendous disaster to humanity,compelling us to seek effective solutions from various perspectives.Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection can induce an increase in host glycolysis,the level of which plays an important role in virus replication and infection,associated with the progression of the disease and a variety of clinical symp-toms and complications.The study on the interaction between host glycolysis and SARS-CoV-2 infec-tion can shed light on the pathogenic mechanism of SARS-CoV-2 and promote the research on related drugs.This article reviews the interactions between SARS-CoV-2 infection and host glycolysis in the hopes of providing a new perspective to understand the relationships between viral infections and disease in terms of metabolic regulation and formulate countermeasures.
李月含;韩露;周文霞
广东药科大学中药学院,广东 广州 510006||军事医学研究院国家安全特需药品全国重点实验室,北京 100850军事医学研究院国家安全特需药品全国重点实验室,北京 100850
药学
新型冠状病毒感染糖酵解相互作用
severe acute respiratory syndrome coronavirus 2infectionglycolysisinteraction
《中国药理学与毒理学杂志》 2024 (008)
610-618 / 9
国家自然科学基金(82141218);中国科学技术协会青年人才托举工程(2022QNRC001) National Natural Science Foundation of China(82141218);and China Association for Science and Technology Youth Talent Lift Project(2022QNRC001)
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