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灵芝酸A药理作用及其机制研究新进展OA北大核心CSTPCD

New advances in pharmacological effects and mechanisms of ganoderic acid A

中文摘要英文摘要

灵芝被广泛应用于食品(保健)、药品和化妆品等领域.灵芝酸A是一种具有重要药理活性的灵芝三萜类化合物.现代药理研究表明,灵芝酸A具有抗肿瘤、抗神经精神系统疾病、肝保护作用、降血脂作用、抗炎和肾保护作用等多种药理作用.本文对灵芝酸A的药理学作用及其机制研究新进展进行梳理与总结,为其进一步开发和应用提供参考.

Ganoderma lucidum is one of the widely-used traditional Chinese medicines.Ganoderma lucidum extract and Ganoderma spore powder are also widely used in foods,health care and cosmetics,and are highly favored by consumers.Ganoderic acid A is one of the main effective components of Ganoderma lucidum triterpenoids.In recent years,a large number of studies have proved that ganoderic acid A has anti-tumor,anti-inflammatory,hepatoprotection,hypolipidemic,renoprotective properties,and has therapeutic potential in psychiatric and neurological disorders.,which has high medicinal value and good prospects for development.Based on review of domestic and foreign literatures in recent years,the new research progress in pharmacology of ganoderic acid A is summarized in this paper in order to provide references for its further development and clinical applications.

谢珍;业康;匡荣;陆静娴;陈碧莲

浙江省食品药品检验研究院 国家药品监督管理局化妆品动物替代试验技术重点实验室,浙江杭州 310052浙江省中药研究所有限公司,浙江杭州 310023浙江省食品药品检验研究院 国家药品监督管理局中成药质量评价重点实验室 浙江杭州 310052

中医学

灵芝酸A药效学药动学

ganoderic acid Apharmacodynamicspharmacokinetics

《中国药理学与毒理学杂志》 2024 (008)

619-632 / 14

浙江省科技计划项目省级重点研发计划(2021C02019) Key Research and Development Program of Zhejiang Province(2021C02019)

10.3867/j.issn.1000-3002.2024.08.007

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