中国药理学与毒理学杂志2024，Vol.38Issue(8)：633-640,8.DOI:10.3867/j.issn.1000-3002.2024.08.008
肾类器官血管化研究进展
Research progress in vascularization of renal organoids
刘鹤 1岳亮 2吴成君 3檀英霞2
作者信息
- 1. 大连理工大学医学部生物医学工程学院,辽宁 大连 116000||军事医学研究院,北京 100850
- 2. 军事医学研究院,北京 100850
- 3. 大连理工大学医学部生物医学工程学院,辽宁 大连 116000
- 折叠
摘要
Abstract
Kidney organoids are induced and differentiated from human pluripotent stem cells(PSCs)or adult stem cells(ASCs)derived from tissue sources,primarily composed of nephron struc-tures.However,due to the absence of a supporting vascular network,kidney organoids often exhibit immature tissue structures and limited growth.Therefore,vascularization in kidney organoids remains a pressing challenge in this field.Currently,the methods such as transplantation into immunodeficient animals,alterations in induced differentiation protocols,utilization of microfluidic chips,and manipula-tion of extracellular matrix and oxygen concentrations may facilitate vascularization of kidney organoids,which provides a new perspective for the scientific study and clinical application of kidney organoids.关键词
肾类器官/血管化/微流控/异种移植/细胞外基质Key words
kidney organoids/vascularization/microfluidics/xenotransplantation/extracellular matrix分类
医药卫生引用本文复制引用
刘鹤,岳亮,吴成君,檀英霞..肾类器官血管化研究进展[J].中国药理学与毒理学杂志,2024,38(8):633-640,8.
