肝切除术与经导管动脉栓塞化疗术治疗原发性肝癌破裂出血的临床效果比较OA

Objective:To compare the clinical efficacy of hepatectomy and transcatheter arterial chemoembolization(TACE)in the treatment of rupture and bleeding in primary liver cancer(PLC).Method:A total of 80 patients with PLC rupture and bleeding who were admitted in Tengzhou Central People's Hospital from October 2018 to October 2023 were selected and divided into TACE group(n=48)and hepatectomy group(n=32)by different treatment method.The TACE group received TACE treatment,while the hepatectomy group received hepatectomy treatment.The surgical related indicators,tumor marker level,postoperative complications,and short-term survival in both groups were compared.Result:The intraoperative bleeding volume and blood transfusion volume in the TACE group were less compared to those in hepatectomy group,the differences were statistically significant(P<0.05).After surgery,the hemoglobin(Hb)levels in both groups were increased compared to preoperative levels,and total bilirubin(TBIL)levels were decreased compared to preoperative levels,the Hb level of the TACE group was higher compared to that of hepatectomy group,and the TBIL level was lower,the differences were statistically significant(P<0.05).After surgery,the alpha fetoprotein(AFP),carcinoembryonic antigen(CEA)levels in both groups were decreased compared to preoperative levels,the differences were statistically significant(P<0.05),there were no statistically significant differences in the TACE group and the hepatectomy group(P>0.05).The incidence of postoperative complications in the TACE group(4.17%)was lower than that in the hepatectomy group(21.88%),the difference was statistically significant(P<0.05).There was no statistically significant difference in short-term survival rate between the TACE group(93.75%)and the hepatectomy group(87.50%)(P>0.05).Conclusion:Both TACE treatment and hepatectomy can improve tumor markers and have higher short-term survival rates in patients with PLC rupture and bleeding.However,TACE has a better hemostatic effect and fewer postoperative complications.