摘要
Abstract
Objective:To explore the distribution characteristics and drug resistance changes of pathogenic bacteria in ventilator-associated pneumonia in Yingtan City People's Hospital from 2020 to 2022.Method:The medical records of 80 patients with ventilator-associated pneumonia admitted to our hospital from January 2020 to December 2022 were retrospectively analyzed.Sputum samples of all patients were collected within 24 h of admission for etiological culture and drug susceptible test.The distribution characteristics of pathogenic bacteria and the change of drug resistance rate of major pathogenic bacteria in 3 years were analyzed.Result:A total of 126 strains of pathogenic bacteria were detected in 80 sputum samples,including 96 strains(76.19%)of Gram negative bacteria,22 strains(17.46%)of Gram positive bacteria and 8 strains(6.35%)of fungus.Acinetobacter baumanii(29.37%),Klebsiella pneumoniae(19.05%),Pseudomonas aeruginosa(17.46%)accounted for the higher proportion.The drug resistance analysis of Acinetobacter baumanii showed that the resistance of Acinetobacter baumanii to Aztreonam and Cefotetan were higher,and the resistance of Compound Sulfamethoxazole was lower.There were no significant differences in resistance rates of each antibiotic of Acinetobacter baumanii in different years(P>0.05).The drug resistance analysis of Klebsiella pneumoniae showed that the drug resistance of Klebsiella pneumoniae to Cefoperazone Sulbactam Sodium and Aztreonam were higher,≥50.00%in each year,and the resistance of Aztreonam and Levofloxacin were lower,<15.00%in each year.The resistance rates of Klebsiella pneumoniae to Aztreonam showed an increasing trend from 2020 to 2022,the difference was statistically significant(P<0.05).The drug resistance analysis of Pseudomonas aeruginosa showed that the drug resistance of Pseudomonas aeruginosa to Cefotetan,Imipenem and Levofloxacin were higher,and the resistance of Piperacillin Sodium Tazobactam Sodium and Compound Sulfamethoxazole were lower.There were no significant differences in resistance rates of each antibiotic of Pseudomonas aeruginosa in different years(P>0.05).Conclusion:In the distribution of pathogenic bacteria of ventilator-associated pneumonia,Acinetobacter baumanii,Klebsiella Pneumoniae,pseudomonas aeruginosa and other Gram negative bacteria are the main bacteria,which have different degrees of drug resistance to various antimicrobial agent,and the resistance rate of Klebsiella pneumoniae to Aztreonam shows an increasing trend.关键词
呼吸机相关性肺炎/病原菌/耐药性Key words
Ventilator-associated pneumonia/Pathogenic bacteria/Drug resistance
