摘要
Abstract
Objective To investigate the clinical features,diagnosis and treatment of coronary artery spasm caused by calcineurin inhibitor tacrolimus,and to review the cardiovascular adverse reactions related to tacrolimus.Methods The clinical data of a patient with coronary artery spasm caused by calcineurin inhibitor tacrolimus who was admitted to Beijing Hospital on June 18,2021 were retrospectively analyzed,and the relevant literature was reviewed.Results This case describes a 58-year-old male patient who developed chest pain symptoms after taking tacrolimus 15 d,diagnosed as coronary artery spasm.Symptoms disappeared and did not recur after discontinuing tacrolimus and adding nitrate and calcium channel blockers.Adverse cardiovascular reactions caused by tacrolimus are relatively rare.The case and the review of the literature summarized 13 cases,including 7 cases of hypertrophic cardiomyopathy,4 cases of coronary artery spasm,and 2 cases of arrhythmia.In terms of treatment,12 cases discontinued or reduced tacrolimus,and 3 patients were additionally prescribed calcium channel blockers,leading to improvement in all cases with a good prognosis.Conclusions Tacrolimus induced coronary artery spasm is rare.Symptoms should be recognized in time,timely withdrawal,Use of nitrates and calcium channel blockers,symptoms in recommended,while tacrolimus should be withdrawal.关键词
钙调磷酸酶抑制剂/他克莫司/冠状动脉痉挛/心血管不良反应/文献回顾Key words
Calcineurin/Tacrolimus/Coronary artery spasm/Adverse cardiovascular events/Literature review
