中国癌症防治杂志2024，Vol.16Issue(4)：461-467,7.DOI:10.3969/j.issn.1674-5671.2024.04.12
术前CT征象联合临床指标预测肝细胞癌中CK19的表达
Preoperative CT signs combined with clinical indicators predict the expression of cytokeratin 19 in hepatocellular carcinoma
摘要
Abstract
Objective To investigate the value of preoperative CT signs combined with clinical indicators in predicting the expression of cytokeratin 19(CK19)in patients with hepatocellular carcinoma(HCC).Methods HCC patients admitted to Guangxi Medical Uni-versity Cancer Hospital from January 2019 to December 2021 were enrolled as the studied objects.The clinical data and CT signs were collected and randomly divided into training group and validation group according to a ratio of 7:3.The independent predictors of CK19 expression was analyzed by Logistic backward stepwise regression and a predictive model was constructed.The receiver operating characteristic(ROC)curve,calibration curve,and decision curve were used to evaluate the predictive efficacy of the model.Results A total of 380 HCC patients were enrolled,of which 68(17.9％)were CK19 positive.Age,AFP,rim arterial phase hyperenhancement,delayed central enhancement,and intratumoral artery were independent predictors of CK19 expression in HCC(all P＜0.05).The area under the curve(AUC)of CK19 expression predicted by the clinical imaging model in the training group and validation group was 0.789 and 0.748,respectively.The calibration curve showed a good fitting degree of the clinical imaging model.The decision curve showed that the clinical image model had good clinical application value.Conclusions Preoperative CT signs combined with age and AFP effectively predict CK19 expression in HCC patients.关键词
肝细胞癌/CT征象/细胞角蛋白19Key words
Hepatocellular carcinoma/CT signs/Cytokeratin 19分类
临床医学引用本文复制引用
张思怡,黄向阳,覃云英,刘丽娟,黄彩云,罗宁斌..术前CT征象联合临床指标预测肝细胞癌中CK19的表达[J].中国癌症防治杂志,2024,16(4):461-467,7.基金项目
广西科技基地和人才专项(桂科AD20238096) （桂科AD20238096）
广西医科大学青年科学基金项目(GXMUYSF202119 （）
GXMUYSF202227) （）
