中国合理用药探索2024，Vol.21Issue(8)：86-90,5.DOI:10.3969/j.issn.2096-3327.2024.08.009
丁苯酞联合阿司匹林、氯吡格雷治疗进展性脑梗死的临床观察
Clinical Observation of Butylphthalide Combined with Aspirin and Clopidogrel in the Treatment of Progressive Cerebral Infarction
摘要
Abstract
Objective:To investigate the clinical efficacy of butylphthalide combined with aspirin and clopidogrel in the treatment of progressive cerebral infarction(PCI).Methods:A total of 106 PCI patients treated in a hospital from September 2021 to September 2023 were selected and assigned to the control group and observation group by random number table method,with 53 patients in each group.The control group was treated with aspirin enteric-coated tablets and clopidogrel bisulfate tablets,whereas the observation group was treated with butylphthalide and sodium chloride injection in addition to the treatment given in the control group,and both groups were continuously treated for 14 days.The neurological function[National Institute of Health Stroke Scale(NIHSS)],neural factors[neuron specific enolase(NSE),matrix metalloproteinase-9(MMP-9),brain-derived neurotrophic factor(BDNF)],cerebral hemodynamic parameters[mean velocity(Vmean),resistance index(RI),pulsatility index(PI)]and adverse reactions were compared between the two groups.Results:After treatment,the NIHSS score,NSE and MMP-9 were decreased in both groups(P<0.05),and were lower in the observation group than those in the control group(P<0.05).The level of BDNF was increased in both groups(P<0.05),and was higher in the observation group than that in the control group(P<0.05).The Vmean and PI were increased in both groups(P<0.05),and were higher in the observation group than those in the control group(P<0.05).The RI was decreased in both groups(P<0.05),and was lower in the observation group than that in the control group(P<0.05).No statistically significant difference in the total incidence of adverse reactions was observed between the two groups(P>0.05).Conclusion:Butylphthalide combined with aspirin and clopidogrel can effectively improve neurological function and cerebral hemodynamic parameters in patients with PCI,and does not increase the risk of adverse reactions.关键词
进展性脑梗死/丁苯酞/阿司匹林/氯吡格雷/神经功能Key words
progressive cerebral infarction/butylphthalide/aspirin/clopidogrel/neurological function分类
医药卫生引用本文复制引用
章华,王芳芳,宋彦..丁苯酞联合阿司匹林、氯吡格雷治疗进展性脑梗死的临床观察[J].中国合理用药探索,2024,21(8):86-90,5.基金项目
河南省医学科技攻关计划(联合共建)项目(LHGJ20191467) （联合共建）
