中国中医药信息杂志2024，Vol.31Issue(9)：12-17,6.DOI:10.19879/j.cnki.1005-5304.202309200
基于"肠道菌群-胆汁酸"途径探讨动脉粥样硬化"土壅木郁"病机的生物学内涵
Exploration on the Biological Connotation of the Pathogenesis of "Earth Congestion and Wood Depression" of Atherosclerosis from "Intestinal Flora-Bile Acids" Pathway
摘要
Abstract
Intestinal flora and bile acid metabolism regulate and influence each other,and an imbalance in the"intestinal flora-bile acid"pathway is closely related to atherosclerosis.Based on TCM theory and clinical practice,it is found that"earth congestion and wood depression"is the key mechanism of atherosclerosis,but its biological connotation needs to be further elucidated.Combined with the results of modern research,it is believed that intestinal flora imbalance is an important foundation of"earth congestion",and bile acid metabolism abnormality is an important manifestation of"wood depression".In the process of atherosclerosis,the imbalance of the"intestinal flora-bile acid"pathway is closely related to the"earth congestion and wood depression"pathogenesis of TCM in atherosclerosis.Exploring the biological connotation of the pathogenesis of"earth congestion and wood depression"of atherosclerosis from the"intestinal flora-bile acids"pathway is of far-reaching significance for clarifying the scientific connotation of TCM theory and guiding the TCM prevention and treatment of atherosclerosis.关键词
动脉粥样硬化/胆汁酸/肠道菌群/土壅木郁Key words
atherosclerosis/bile acids/intestinal flora/earth congestion and wood depression分类
中医学引用本文复制引用
孟浩先,金华,席金梦,何彦虎,司美龙,叶路亮,侯田田..基于"肠道菌群-胆汁酸"途径探讨动脉粥样硬化"土壅木郁"病机的生物学内涵[J].中国中医药信息杂志,2024,31(9):12-17,6.基金项目
国家自然科学基金(82160886、81860832) （82160886、81860832）
甘肃省省级重点人才项目(2023年) （2023年）
甘肃省自然科学基金(20JR10RA315、22JR5RA579) （20JR10RA315、22JR5RA579）
甘肃中医药大学中医学一级学科"岐黄英才"导师专项基金(ZYXKBD-202203) （ZYXKBD-202203）
