中国中医药信息杂志2024，Vol.31Issue(9)：58-65,8.DOI:10.19879/j.cnki.1005-5304.202309549
基于数据挖掘探讨张炳厚治疗糖尿病肾病用药规律
Exploration on the Medication Law of Zhang Binghou in Treating Diabetic Kidney Disease Based on Data Mining
摘要
Abstract
Objective To analyze Professor Zhang Binghou's medication experience in the treatment of diabetic kidney disease using data mining methods;To screen the core medicinal pairs and medicinal groups.Methods Prescriptions of diabetic kidney disease of Professor Zhang Binghou from the outpatient department of Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University were selected from January 2014 to December 2021.TCM Inheritance Platform System 2.5,SPSS Modeler 18 and SPSS Statistics 21 software were used for association rules,clustering analysis and factor analysis to summarize the medication frequency,properties and tastes and meridians,and medicinal pairs and combinations.Results A total of 161 prescriptions were included,involving 188 kinds of Chinese materia medica,with a total frequency of 2 220 time.The kinds of Chinese materia medica with higher frequency were Rehmannize Radix et Praeparata,Testudinis Carapax et Plastrum,Astragali Radix,Rehmannine Radix,etc.The main properties were cold and warm,the main tastes were sweet and bitter,and the main meridians were kidney,liver and spleen meridians.A total of 14 drug pair association rules were obtained,with 27 commonly used drug combinations.Clustering analysis extracted 10 combinations based on the spectrum,and factor analysis extracted 14 common factors.Conclusion Professor Zhang Binghou's treatment for diabetic kidney disease takes nourishing the true yin and clearing away damp-heat as the main treatment method,and at the same time,it pays attention to tonifying kidney,consolidating essence,nourishing yin and containing yang,promoting blood circulation and removing blood stasis,etc.,which embodies Professor Zhang Binghou's unique academic thought of treating diabetic kidney disease.关键词
中医传承辅助平台/张炳厚/糖尿病肾病/数据挖掘/用药规律Key words
TCM Inheritance Platform System/Zhang Binghou/diabetic kidney disease/data mining/medication law分类
医药卫生引用本文复制引用
李萌雨,商海涛,张世文,赵文景,蔡朕,庞欣欣,尹笑丹..基于数据挖掘探讨张炳厚治疗糖尿病肾病用药规律[J].中国中医药信息杂志,2024,31(9):58-65,8.基金项目
国家中医药管理局中医药古籍文献和特色技术传承专项(GZY-KJS-2020-039) （GZY-KJS-2020-039）
国家中医临床研究基地科研项目(2019JDZX2119、2022JDZX139) （2019JDZX2119、2022JDZX139）
河南省自然科学基金(202300410256) （202300410256）
