中国中医药信息杂志2024，Vol.31Issue(9)：145-151,7.DOI:10.19879/j.cnki.1005-5304.202401415
补肾解毒化瘀法治疗较高危骨髓增生异常综合征的真实世界研究
A Real-world Study on Bushen Jiedu Huayu Method in the Treatment of Higher-risk Myelodysplastic Syndromes
摘要
Abstract
Objective To explore the performance of routine blood test parameters,bone marrow parameters and the risk factors of leukemia conversion in higher-risk patients with myelodysplastic syndrome(MDS)treated with Bushen Jiedu Huayu Method in the real world.Methods The clinical data of 162 patients with higher-risk MDS who were admitted to the Department of Hematology,Xiyuan Hospital,China Academy of Chinese Medical Sciences from September 2017 to September 2022 were collected,and their clinical data,blood routine parameters,and bone marrow parameters were analyzed.Results A total of 162 higher-risk MDS patients were included,and the overall effective rate of the combination of traditional Chinese and Western medicine treatment,mainly using Bushen Jiedu Huayu Method being 48.8%.Patients with higher-risk MDS who were younger than 70 years old were more likely to obtain curative effect when treated with Bushen Jiedu Huayu Method combined with chemotherapy(P<0.05).After treatment with Bushen Jiedu Huayu Method,PLT levels in higher-risk MDS patients were significantly higher than those before treatment(P<0.05),and PLT levels in the ineffective group increased more significantly(P<0.05).After treatment,the HGB level in the effective group significantly increased(P<0.05).After treatment,the proportion of bone marrow granulocytes,megakaryocytes and lymphocytes in higher-risk MDS patients were significantly higher than those before treatment(P<0.05).Conclusion Bushen Jiedu Huayu Method,mainly using arsenic containing TCM compound,can treat higher-risk MDS.It can increase the HGB content and PLT level of patients,increase the proportion of bone marrow granulocytes,megakaryocytes and lymphocytes,and also play a certain role in reducing the proportion of bone marrow primitive cells,namely demethylation.关键词
真实世界/补肾解毒化瘀法/较高危骨髓增生异常综合征/血常规/骨髓细胞形态学Key words
real world/Bushen Jiedu Huayu Method/higher-risk myelodysplastic syndromes/blood routine test/bone marrow cell morphology分类
医药卫生引用本文复制引用
刘健,李芮,杨秀鹏,王洪志,许勇钢,陈卓,王德秀,肖海燕,唐旭东..补肾解毒化瘀法治疗较高危骨髓增生异常综合征的真实世界研究[J].中国中医药信息杂志,2024,31(9):145-151,7.基金项目
国家自然科学基金面上项目(82074258、82274502) （82074258、82274502）
第二批北京市研究型病房示范建设项目(BCRW202108) （BCRW202108）
中国中医科学院科技创新工程重大攻关项目(CI2021A01701) （CI2021A01701）
