中国中医药信息杂志2024，Vol.31Issue(9)：185-190,6.DOI:10.19879/j.cnki.1005-5304.202310001
中药调控自噬治疗IgA肾病研究进展
Research Progress in the Regulation of TCM for Autophagy in the Treatment of IgA Nephropathy
摘要
Abstract
IgA nephropathy is a common primary glomerular disease,and autophagy plays an important role in maintaining the homeostasis of the internal environment.Dysfunction of cellular autophagy can affect the occurrence and development of IgA nephropathy.This article focused on the molecular mechanism of TCM regulating autophagy in renal intrinsic cells,and found that TCM extracts and formulas mainly regulate autophagy through PI3K/Akt/mTOR,TLR4/NF-κB,MAPK,Nrf2/HO-1,NLRP3 and other signaling pathways.Furthermore,it could intervene in pathological damage such as renal fibrosis,inflammation,and oxidative stress,delaying the progression of IgA nephropathy,in order to provide reference for the clinical treatment and new drug development of IgA nephropathy.关键词
IgA肾病/自噬/中医药/综述Key words
IgA nephropathy/autophagy/TCM/review分类
中医学引用本文复制引用
陈宇,黄国东,覃婷,张泽朝,王慧玲,刘少芳,莫超..中药调控自噬治疗IgA肾病研究进展[J].中国中医药信息杂志,2024,31(9):185-190,6.基金项目
广西名中医传承工作室(2021年) （2021年）
广西岐黄学者培养项目(2021年) （2021年）
广西医学高层次骨干人才培养"139"计划(G202002014) （G202002014）
广西中医药重点学科(中西医结合临床)建设项目(2020年) （中西医结合临床）
