中药调控自噬治疗IgA肾病研究进展OACSTPCD
Research Progress in the Regulation of TCM for Autophagy in the Treatment of IgA Nephropathy
IgA肾病是常见原发性肾小球疾病,自噬对维持内环境稳态起重要作用,细胞自噬功能障碍可影响IgA肾病发生发展.本文围绕自噬梳理中药调控肾脏固有细胞自噬的分子机制,发现中药提取物及中药复方主要通过PI3K/Akt/mTOR、TLR4/NF-κB、MAPK、Nrf2/HO-1、NLRP3等信号通路调节细胞自噬活性,进而干预肾纤维化、炎症、氧化应激等病理损害,延缓IgA肾病进展,为IgA肾病临床治疗及新药研发提供参考.
IgA nephropathy is a common primary glomerular disease,and autophagy plays an important role in maintaining the homeostasis of the internal environment.Dysfunction of cellular autophagy can affect the occurrence and development of IgA nephropathy.This article focused on the molecular mechanism of TCM regulating autophagy in renal intrinsic cells,and found that TCM extracts and formulas mainly regulate autophagy through PI3K/Akt/mTOR,TLR4/NF-κB,MAPK,Nrf2/HO-1,NLRP3 and other signaling pathways.Furthermore,it could intervene in pathological damage such as renal fibrosis,inflammation,and oxidative stress,delaying the progression of IgA nephropathy,in order to provide reference for the clinical treatment and new drug development of IgA nephropathy.
陈宇;黄国东;覃婷;张泽朝;王慧玲;刘少芳;莫超
广西中医药大学附属国际壮医医院,广西 南宁 530000广西中医药大学附属瑞康医院,广西 南宁 530000广西中医药大学第一附属医院,广西 南宁 530000
中医学
IgA肾病自噬中医药综述
IgA nephropathyautophagyTCMreview
《中国中医药信息杂志》 2024 (009)
185-190 / 6
广西名中医传承工作室(2021年);广西岐黄学者培养项目(2021年);广西医学高层次骨干人才培养"139"计划(G202002014);广西中医药重点学科(中西医结合临床)建设项目(2020年)
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