中国中药杂志2024，Vol.49Issue(15)：3986-3997,12.DOI:10.19540/j.cnki.cjcmm.20240517.102
中药高价值活性成分的生物与化学合成研究进展
Biological and chemical synthesis of high-value active ingredients in traditional Chinese medicine
摘要
Abstract
Traditional Chinese medicine(TCM)contains many high-value active ingredients,such as artemisinin,paclitaxel,vinblastine,and vincristine.However,these ingredients are present in low concentrations in the original plants,and their complex structures make extraction and separation challenging.To protect the limited resources of TCM,researchers have employed total chemical synthesis strategies to prepare structurally complex high-value active ingredients in TCM.However,harsh reaction conditions,lengthy routes,and low yields pose challenges to total chemical synthesis.With the development of synthetic biology,many high-value active ingredients can now be prepared through bio-cell engineering,complementing total chemical synthesis and offering new strategies for the preparation of high-value active ingredients in TCM.This article briefly reviewed the research progress in the biological and chemical synthesis of representative high-value active ingredients in TCM,including β-elemene,artemisinin,tanshinone,vincristine,and homoharringtonine.This article proposed a research paradigm that combined biological and chemical synthesis,including chemical enzyme-mediated structural modification of high-value active ingredients in TCM,semi-synthetic production of high-value active ingredients in TCM using biological synthesis,and biomimetic synthesis to facilitate the biological synthesis pathway of high-value active ingredients in TCM.It provided an important reference for the synthesis of high-value active ingredients in TCM.关键词
中药/高价值活性成分/生物合成/化学合成Key words
traditional Chinese medicine/high-value active ingredients/biological synthesis/chemical synthesis引用本文复制引用
赵雅秋,袁媛..中药高价值活性成分的生物与化学合成研究进展[J].中国中药杂志,2024,49(15):3986-3997,12.基金项目
中国中医科学院科技创新工程项目(CI2021A04118,CI2021B014) （CI2021A04118,CI2021B014）
中央级公益性科研院所基本科研业务费专项(ZZXT202202) （ZZXT202202）
中央本级重大增减支项目(2060302) （2060302）
国家杰出青年科学基金项目(82325049) （82325049）
