中国卒中杂志2024，Vol.19Issue(7)：785-789,5.DOI:10.3969/j.issn.1673-5765.2024.07.008
甘油三酯对高血压患者认知功能的影响:一项社区人群的长期队列研究
Effect of Triglyceride on Cognitive Function in Hypertensive Patients:A Long-Term Cohort Study in a Community-Based Population
摘要
Abstract
Objective To investigate the effects of TG levels on cognitive function in community patients with hypertension. Methods This study was a prospective cohort study based on community population.The subjects were hypertensive over 40 years old in Beiqijia Community Health Service Center,Changping District,Beijing.The first collection of information on demographics,medical history,laboratory tests,and assessment of cognitive function(using the MoCA)was completed from 2015 to 2016.Cognitive function was reassessed in 2023 after a follow-up of 7-8 years.Cognitive decline was defined as △MoCA(baseline MoCA score-follow-up MoCA score).Multivariate linear regression was used to analyze the effects of TG levels on cognitive decline. Results A total of 338 patients[mean age(59.1±6.8)years,111(32.8％)males]were included.TG levels were positively correlated with cognitive decline(△MoCA)(β=0.172,P=0.025),and were mainly correlated with the decline of visuospatial executive function(β=0.152,P=0.045). Conclusions There is an independent correlation between the increased TG level and the decreased cognitive function in community patients with hypertension,and it may primarily affect the visuospatial executive function.关键词
甘油三酯/认知障碍/视空间执行功能/高血压Key words
Triglyceride/Cognitive impairment/Visuospatial executive function/Hypertension分类
医药卫生引用本文复制引用
贾娇坤,刘改芬,刘艳芳,赵性泉,陈静..甘油三酯对高血压患者认知功能的影响:一项社区人群的长期队列研究[J].中国卒中杂志,2024,19(7):785-789,5.基金项目
脑卒中高危人群筛查和干预项目(财政部、国家卫生计生委[2015]82号 （）
财政部、国家卫生健康委、国家疾控局[2023]63号) （）
首都医科大学附属北京天坛医院苗圃工程项目(2023MP05) （2023MP05）
