甘油三酯对高血压患者认知功能的影响:一项社区人群的长期队列研究OA北大核心CSTPCD

Objective To investigate the effects of TG levels on cognitive function in community patients with hypertension. Methods This study was a prospective cohort study based on community population.The subjects were hypertensive over 40 years old in Beiqijia Community Health Service Center,Changping District,Beijing.The first collection of information on demographics,medical history,laboratory tests,and assessment of cognitive function(using the MoCA)was completed from 2015 to 2016.Cognitive function was reassessed in 2023 after a follow-up of 7-8 years.Cognitive decline was defined as △MoCA(baseline MoCA score-follow-up MoCA score).Multivariate linear regression was used to analyze the effects of TG levels on cognitive decline. Results A total of 338 patients[mean age(59.1±6.8)years,111(32.8％)males]were included.TG levels were positively correlated with cognitive decline(△MoCA)(β=0.172,P=0.025),and were mainly correlated with the decline of visuospatial executive function(β=0.152,P=0.045). Conclusions There is an independent correlation between the increased TG level and the decreased cognitive function in community patients with hypertension,and it may primarily affect the visuospatial executive function.