中国卒中杂志2024，Vol.19Issue(8)：931-937,7.DOI:10.3969/j.issn.1673-5765.2024.08.011
基于3D-ASL、DKI序列探讨脑小血管病脑白质高信号及其半暗带与认知障碍的相关性研究
Exploring the Correlation between White Matter Hyperintensity,White Matter Hyperintensity Penumbra and Cognitive Impairment in Cerebral Small Vessel Disease Based on 3D-ASL and DKI Sequences
摘要
Abstract
Objective To investigate the relationship between blood perfusion,microstructural damage that in different subtypes of white matter hyperintensity(WMH)and white matter hyperintensity penumbra(WMH-P),and cognitive impairment. Methods The patients with cerebral small vessel disease(CSVD)patients with the WMH rating of modified Fazekas grade Ⅰ-Ⅱ at Tangshan Gongren Hospital from May 2021 to March 2023 were included.The 3.0 T MRI scan[three-dimensional arterial spin labeling(3D-ASL),diffusion kurtosis imaging(DKI)sequences]were conducted on these patients.The blood perfusion index[cerebral blood flow(CBF)]and the indexes[axial diffusivity(AD),mean diffusivity(MD),radial diffusivity(RD),axial kurtosis(AK),mean kurtosis(MK),radial kurtosis(RK),and fraction anisotropy(FA)]reflecting the microstructural changes within the deep white matter hyperintensity(DWMH)region of interest(ROI1)and its WMH-P(ROI1-1 in the inner layer and ROI1-2 in the outer layer),as well as periventricular white matter hyperintensity(PVWMH)(ROI2)and its WMH-P(ROI2-1 in the inner layer and ROI2-2 in the outer layer)of patients were analyzed.The cognitive function of patients was analyzed.The Spearman correlation was used to analyze the relationship between the above indexes reflecting blood perfusion changes and microstructural changes in different subtypes of WMH(DWMH and PVWMH)and its corresponding WMH-P and the severity of cognitive impairment. Results A total of 61 patients with CSVD were included,with an average age of(61±1)years.The RD value(r=0.296)in DWMH(ROI1)was positively correlated with the severity of cognitive impairment,while the MK value(r=-0.287)and the RK value(r=-0.315)were negatively correlated with the severity of cognitive impairment.The values of AD(ROI1-1:r=0.274;ROI1-2:r=0.261),MD(ROI1-1:r=0.370;ROI1-2:r=0.387),and RD(ROI1-1:r=0.411;ROI1-2:r=0.430)in WMH-P were positively correlated with the severity of cognitive impairment,while the values of AK(ROI1-1:r=-0.270;ROI1-2:r=-0.297),MK(ROI1-1:r=-0.367;ROI1-2:r=-0.325),RK(ROI1-1:r=-0.379;ROI1-2:r=-0.309),and FA(ROI1-1:r=-0.286;ROI1-2:r=-0.256)were negatively correlated with the severity of cognitive impairment.The MK value(r=0.354)and RK value(r=0.293)in PVWMH were positively correlated with the severity of cognitive impairment.There was no significant correlation between the indexes that reflecting the changes of microstructures in WMH-P and cognitive impairment.The CBF values in WMH and WMH-P were not significantly correlated with the severity of cognitive impairment. Conclusions In CSVD patients,the microstructural damages of DWMH,WMH-P of DWMH,and PVWMH were weakly correlated with cognitive impairment,but the microstructure in WMH-P of PVWMH was not correlated with cognitive impairment.In addition,blood perfusion in WMH and WMH-P was not correlated with cognitive impairment.关键词
三维动脉自旋标记/弥散峰度成像/脑白质高信号/脑白质高信号半暗带/认知功能Key words
Three-dimensional arterial spin labeling/Diffusion kurtosis imaging/White matter hyperintensity/White matter hyperintensity penumbra/Cognition分类
医药卫生引用本文复制引用
高德瑜,王余,王欣,赵彤彤,王素洁..基于3D-ASL、DKI序列探讨脑小血管病脑白质高信号及其半暗带与认知障碍的相关性研究[J].中国卒中杂志,2024,19(8):931-937,7.基金项目
河北省重点研发计划项目—民生科技专项(20377743D) （20377743D）
