Regulation of fatty acid synthase on tumor and progress in the development of related therapiesOACSTPCDMEDLINE
Regulation of fatty acid synthase on tumor and progress in the development of related therapies
Fatty acid synthase(FASN)is an essential molecule in lipid metabolic pathways,which are crucial for cancer-related studies.Recent studies have focused on a comprehensive understanding of the novel and important regulatory effects of FASN on malignant biological behavior and immune-cell infiltration,which are closely related to tumor occurrence and development,immune escape,and immune response.FASN-targeting antitumor treatment strategies are being developed.Therefore,in this review,we focused on the effects of FASN on tumor and immune-cell infiltration and reviewed the progress of related anti-tumor therapy development.
Rilan Bai;Jiuwei Cui
Cancer Center,the First Hospital of Jilin University,Changchun,Jilin 130021,China
NeoplasmFatty acid synthaseFatty acid synthase inhibitorImmune regulation
《中华医学杂志（英文版）》 2024 (016)
1894-1902 / 9
This work was supported by grants from the Jilin Provincial Science and Technology Department(No.20190303146SF)and Jilin Provincial Department of Finance Project(No.JLSWSRCZX2020-0023).
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