中国现代医生2024，Vol.62Issue(23)：7-11,20,6.DOI:10.3969/j.issn.1673-9701.2024.23.002
精神分裂症HCY、PRL及炎性因子与认知功能的相关性及疗效分析
Correlation and treatment of HCY,PRL,inflammatory factors and cognitive function in schizophrenia
摘要
Abstract
Objective To explore the brain metabolic hormone homocysteine in patients with schizophrenia homocysteine(HCY),prolactin(PRL)in its correlation with cognitive function,mining of repetitive transcranial magnetic stimulation(rTMS)combined with olanzapine for the disease,in order to interpret the influence mechanism of brain metabolic hormones and cognitive function,at the same time,mining rTMS and olanzapine to enrich research in this field,to provide reference for related studies.Methods The data of 128 schizophrenia patients treated in the hospital from June 2021 to August 2023 were selected for retrospective analysis,divided into the observation group 72 cases combined rTMS with olanzapine and the control group 56 cases(olanzapine monotherapy).Serum serum HCY,PRL,positive and negative syndrome scale(PANSS),interleukin(IL)-12,tumor necrosis factor(TNF)-α and their associations were analyzed in both groups.The incidence of adverse effects was compared between the two groups.Results After treatment,the levels of PRL,HCY,IL-12,and TNF-α in the observation group were lower than those of the control group,with significant and statistically significant differences(P<0.05).Under the interaction,time point and between groups,the PANSS scores of the two groups changed due to the time passage of different treatment methods,but the observation group was lower than the control group,with significant differences(P<0.05).Treatment was negatively associated with HCY,PRL,IL-12,TNF-α,and PANSS,and HCY,PRL,IL-12,TNF-α,and PANSS were positively associated(P<0.05).The incidence of headache,impaired memory,drowsiness,and adverse reaction events in the observed group was lower than that in the control group,and the difference was significant(P<0.05).Conclusion After rTMS combined with olanzapine treatment,schizophrenia patients can reduce HCY and PRL hormone levels,alleviate inflammation,reduce adverse reactions,and improve cognitive function.关键词
精神分裂症/重复经颅磁刺激/奥氮平/催乳素/血清同型半胱氨酸Key words
Schizophrenia/Repetitive transcranial magnetic stimulation/Olanzapine/Prolactin/Serum homocysteine分类
医药卫生引用本文复制引用
杨行,张晓静,范加琳..精神分裂症HCY、PRL及炎性因子与认知功能的相关性及疗效分析[J].中国现代医生,2024,62(23):7-11,20,6.基金项目
浙江省医药卫生科技计划项目(2024KY1877) （2024KY1877）
