中国现代医生2024，Vol.62Issue(23)：57-62,6.DOI:10.3969/j.issn.1673-9701.2024.23.013
血浆NGAL水平与稳定性冠心病患者冠状动脉病变程度的相关性研究
Association of neutrophil gelatinase-associated lipocalin and severity of coronary stenosis in patients with stable coronary artery disease
摘要
Abstract
Objective To investigate the association of neutrophil gelatinase-associated lipocalin(NGAL)and severity of coronary stenosis in patients with stable coronary artery disease(SCAD).Methods Totally 144 patients who underwent coronary angiography firstly due to suspected coronary artery disease were enrolled.The patients were divided into SCAD group(n=101)and non-CAD group(n=43),and the clinical data were compared.The SCAD group was fuether divided into three subgroups accoding to Gensini score:mild stenosis group(Gensini<16,n=32),moderate stenosis(16≤Gensini<30,n=33)and severe stenosis group(Gensini≥36,n=35).The clinical data of each group were compared.Odinal Logistic regression was used to analysis the influencing factors of severe stenosis.The receiver operating characteristic(ROC)curve was performed to evaluated the ability of NGAL in discriminating severe stenosis.Results Serum NGAL,high sensitive C-reactive protein(hs-CRP)level in SCAD group were higher than those in non-CAD group(P<0.01).Comparing with mild and moderate stenosis groups,NGAL and hs-CRP level were more higher in severe stenosis group(P<0.01).Multivariable Logistic regression analysis showed that NGAL and hs-CRP were independent risk factors for severe coronary stenosis(both P<0.05).Receiver operating characteristic(ROC)curve analysis showed that the areas under the curve of NGAL and hs-CRP were 0.771,0.702 respectively(both P<0.01).The difference between two AUCs was 0.069 which was insignificant(P>0.05).Conclusion Serum NGAL increased is closely associated with severe coronary stenosis in patients with SCAD,which has a certain ability of discriminating severity of coronary stenosis.关键词
冠心病/冠状动脉狭窄程度/Gensini评分Key words
Coronary artery disease/Coronary stenosis/Gensini score分类
医药卫生引用本文复制引用
朱莉,何鸣皓,周美丽,王生超,陈琨..血浆NGAL水平与稳定性冠心病患者冠状动脉病变程度的相关性研究[J].中国现代医生,2024,62(23):57-62,6.基金项目
浙江省金华市公益性技术应用研究项目(2023-4-071,2022-4-099) （2023-4-071,2022-4-099）
