中国现代医生2024，Vol.62Issue(23)：68-72,5.DOI:10.3969/j.issn.1673-9701.2024.23.015
A型肉毒毒素对红斑毛细血管扩张型玫瑰痤疮疗效评价及皮肤镜特征分析
Evaluation of the therapeutic effect of botulinum toxin type a in patients with rosacea erythema telangiectasia and analysis of dermoscopic characteristics
摘要
Abstract
Objective To evaluate the therapeutic effect of botulinum toxin type A(BTX-A)in patients with rosacea erythema telangiectasia and analyze the characteristics of dermoscopy.Methods Thirty patients with erythema telangiectasia rosacea treated in our hospital from January 2021 to August 2023 were collected as the observation targets.All of them received oral drugs(doxycycline hydrochloride combined with hydroxychloroquine sulfate),and were randomized,double-blind,face-divided.The patients with rosacea were injected with botulinum toxin type A(treatment side)and normal saline(control side)respectively,and the skin physiological indexes(transepidermal water loss,oil content,cuticle water content,erythema index)of the patients before and after treatment were compared.The vascular changes before and after dermoscopic treatment were analyzed,and the incidence of adverse reactions of the patients were calculated.Results After treatment,compared with the control side,the water loss,erythema index and oil content in the epidermis of the treatment side were decreased,and the water content in the stratum corneum was increased after treatment,with statistical significance(P<0.05).There was no difference before and after treatment on the control side(P>0.05).On the treatment side,the therapeutic effect was the best at 4 weeks after treatment,and the effect lasted until the 8th week,with no statistical significance(P>0.05),and the therapeutic effect was weakened at 8 weeks to 12 weeks,with statistical significance(P<0.05).The results of dermoscopy showed that after 4 weeks of treatment,compared with before treatment,the distribution proportion of dark red background,red background and polygonal blood vessels decreased,while the distribution proportion of light red background,linear blood vessels,branched blood vessels and punctured blood vessels increased,with statistical significance(P<0.05).There were no significant differences in yellow and red background and blood vessel distribution(P>0.05).The incidence of adverse reactions was 6.67%in the control group and 10.00%in the treatment group,with no statistical difference between the two groups(P>0.05).Conclusion BTX-A has a significant improvement effect on the symptoms of erythematous telangiectatic rosacea with high safety.关键词
红斑毛细血管扩张/玫瑰痤疮/A型肉毒毒素/皮肤镜Key words
Erythema telangiectasia/Rosacea/Botulinum toxin Type A/Dermoscopy分类
医药卫生引用本文复制引用
李嫦嫦,林晓琼..A型肉毒毒素对红斑毛细血管扩张型玫瑰痤疮疗效评价及皮肤镜特征分析[J].中国现代医生,2024,62(23):68-72,5.基金项目
浙江省温州市基础性医疗卫生科技项目(Y20210956) （Y20210956）
