妊娠期糖尿病血脂、凝血功能指标检测意义及对妊娠结局的预测价值分析OA

Objective:To analyze the significance of blood lipid and coagulation function in patients with gestational diabetes mellitus(GDM)and its predictive value for pregnancy outcome.Methods:76 cases of GDM patients admitted to our hospital from May 2020 to May 2023 were selected as the GDM group,and 50 cases of normal pregnant women were selected as the control group.All the participants were followed up to pregnancy,and the GDM group was divided into two subgroups accord-ing to different pregnancy outcomes:normal delivery group and adverse pregnancy Group,58 cases,18 cases,respectively.The clinical data of the participants were retrospectively analyzed,the examination indexes of normal delivery group and adverse pregnancy Group,and the correlation between blood coagulation function,blood lipid indexes and insulin resistance degree of GDM patients were analyzed by Pearson method,the predictive value of blood lipid combined with coagulation function index on GDM adverse pregnancy outcome was analyzed.Results:TG,TC,LDL-C,D-D,FIB and insulin resistance index in GDM group were higher than those in control group,and APTT,PT and insulin secretion index were lower than those in control group(P<0.05);TG,LDL-C,D-D and FIB in adverse pregnancy Group were higher than those in normal delivery group,APTT and PT were lower than those in normal delivery group(P<0.05).Pearson correlation analysis showed that TG,LDL-C,both FIB and D-D were positively correlated with insulin resistance Index(P<0.05)and negatively correlated with insulin secretion Index(P<0.05);the sensitivity,specificity and area under the curve(ACC)of blood lipid combined with coagula-tion function index to predict GDM adverse pregnancy outcome were 92.65%,87.76%and 0.910%respectively.Conclusion:The abnormal changes of blood lipid and coagulation function are related to the occurrence of GDM,and the combined detection has a high predictive value for pregnancy outcome,which can guide clinical diagnosis and treatment.