经皮穴位电刺激对早期肺癌患者麻醉诱导期血流动力学和麻醉药用量影响随机对照研究OA北大核心CSTPCD

Objective To explore the effect of transcutaneous electrical acupoint stimulation(TEAS)on hemodynamic stability and dosage of anesthetics in patients with early-stage lung cancer.Methods Totally 70 patients undergoing video-assisted thoracic surgery because of lung cancer were recruited and randomly assigned to the TEAS group and the control group using the random number table,35 cases in each group.For patients in the TEAS group,electrical stimulation was started 30 min before surgery at bilateral Neiguan(PC6)and Quchi(LI11)acupoint with a frequency of 2/100 Hz and ended till the operation was finished.In the control group,electrodes were connected to the two acupoints without electrical stimulation.The same anesthesia technique and principal of medication were applied in all the patients recruited.Blood pressure and heart rate before anesthesia(T0),after anesthesia induction(T1),immediately after intubation(T2)and 5 min after intubation(T3)were recorded.Dosage of anesthetic drugs(including propofol,remifentanil and rocuronium bromide)were observed.The incidence of adverse cardiovascular events,postoperative dizziness,nausea,vomiting and time of stay in the postanesthesia care unit(PACU)were recorded.Results Compared with the control group,patients in TEAS group showed a significant lower blood pressure and heart rate right after intubation[(103±6)mmHg vs(94±7)mmHg,P=0.001;(91±8)bpm vs(80±10)bpm,P=0.001].The dosage of intraoperative remifentanil[(1.18±0.48)mg vs(0.89±0.32)mg,P=0.004)]and time of stay in PACU(53.2±6.8)min vs(46.2±6.0)min,P=0.001]were significantly reduced.Conclusion TEAS helps to maintain hemodynamic stability during anesthesia induction,reduces dosage of anesthetic and shortens the time of stay in PACU among patients undergoing video-assisted thoracic surgery diagnosed with early-stage lung cancer.(China Clinical Trial Registry No.ChiCTR2200057529)