中国中西医结合杂志2024，Vol.44Issue(8)：921-927,7.DOI:10.7661/j.cjim.20240624.025
龙柴降血方治疗骨髓增殖性肿瘤多中心随机对照研究
Longchai Jiangxue Formula for Myeloproliferative Neoplasms:A Multicenter Randomized Controlled Trial
摘要
Abstract
Objective To evaluate the efficacy and safety of Longchai Jiangxue Formula(LCJX)in the treatment of myeloproliferative neoplasm(MPN).Methods A multicenter double-blinded randomized controlled trial was conducted.One hundred patients with MPN were randomly assigned to the experimental group and control group,with 50 patients in each group.Both groups received conventional treatment and Yigong Formula.The experimental group received LCJX additionally.The treatment lasted for 4 months.The effective rate,blood cell counts,MPN-10 scores,disease progression,and thrombotic or bleeding events were observed.The adverse events were recorded during the treatment.Results A total of 40 cases in the experimental group and 41 cases in the control group completed the trial and were included for statistical analysis.Compared with the control group,the effective rate increased in the experimental group(86.5％vs.56.1％,P＜0.05),the platelet count and hematocrits were decreased in the experimental group(P＜0.05),the total MPN-10 scores,the symptom score of early satiety,and the symptom score of night sweats were all declined in the experimental group(P＜0.05).No disease progression,thrombotic or bleeding events occurred during the treatment.Compared with the control group,the rate of hepatic dysfunction was decreased in the experimental group(5.0％vs.9.7％,P＜0.05),and no adverse events except for mild hepatic dysfunction were observed in both groups during the treatment.Conclusions LCJX can increase the effective rate,decrease blood counts,and improve symptoms in the treatment of MPN,with no more adverse events.LCJX is proven to be effective and safe in the treatment of MPN.关键词
骨髓增殖性肿瘤/原发性血小板增多症/真性红细胞增多症/中医药/龙柴降血方/中西医结合Key words
myeloproliferative neoplasms/essential thrombocythemia/polycythemia vera/Chinese medicine/Longchai Jiangxue Formula/integrative medicine引用本文复制引用
邹吉轩,杨二鹏,牛继聪,王明镜,谌海燕,王国姿,邓少兰,王贺,张明辉,胡晓梅,王德好,王子卿,丁晓庆,邸海侠,曾英坚,付海英,孙岸弢,李雨蒙..龙柴降血方治疗骨髓增殖性肿瘤多中心随机对照研究[J].中国中西医结合杂志,2024,44(8):921-927,7.基金项目
中国中医科学院科技创新工程重大攻关项目(No.CI2021A01702) （No.CI2021A01702）
国家自然科学基金面上项目(No.82174360) （No.82174360）
