中药材2024，Vol.47Issue(2)：365-370,6.DOI:10.13863/j.issn1001-4454.2024.02.017
玉竹地上部位化学成分及其α-葡萄糖苷酶抑制活性研究
Study on the Chemical Constituents from the Aerial Parts of Polygonatum odoratum and α-Glucosidase Inhibitory Activity
摘要
Abstract
Objective:To study the chemical constituents from the aerial parts of Polygonatum odoratum and the inhibition on α-glucosidase activity.Methods:The 75％methanol extract from the aerial parts of Polygonatum odoratum was isolated and purified by va-rious chromatographic techniques,such as macroporous resin HP-20,Sephadex LH-20,MCI gel CHP 20P,Chromatorex C18,semi-pre-parative HPLC and others.The structures were identified on the basis of 1H-NMR,13C-NMR.In addition,the α-glucosidase inhibitory activity of the compounds were evaluated by pharmacological methods simultaneously.Results:Sixteen compounds were isolated from the aerial parts of Polygonatum odoratum and identified as p-hydroxybenzoic acid(1),6-C-glucosylapigenin(2),isoscoparine(3),isoquer-citrin(4),saponarin(5),kaempferol-3-O-β-rutinoside(6),rutin(7),isorhamnetin-3-O-rutinoside(8),2″-O-glucosylvitexin(9),4″-O-glucosylvitexin(10),vitexin-2″-O-β-D-(6′″-acetyl)-glucoside(11),isovitexin-2″-O-β-D-glucoside(12),apigenin-6-C-arabinosylglu-coside(13),quercetin-7-O-[α-L-rhamnopyranosyl(1→6)-β-D-galactopyranoside](14),chrysoeriol-7-O-sophoroside(15),7-O-[β-D-glicopiranosil-(1→6)-β-D-apiofuranosil]crisoeriol(16),respectively.Some of the compounds were also screened for α-glucosidase in-hibitory activity.Conclusion:Among them,compounds 2 to 6,10 to 16 are isolated from Polygonatum odoratum for the first time,com-pound 2 shows significant inhibitory effect on α-glucosidase.关键词
玉竹/化学成分/α-葡萄糖苷酶Key words
Polygonatum odoratum(Mill.)Druce/Chemical constituents/α-Glucosidase分类
医药卫生引用本文复制引用
安涑闽,王亚凤,葛利,何瑞杰,庞闹,黄永林,杨克迪..玉竹地上部位化学成分及其α-葡萄糖苷酶抑制活性研究[J].中药材,2024,47(2):365-370,6.基金项目
广西科技重大专项(桂科AA22096020) （桂科AA22096020）
广西重点研发计划(桂科AB22035019) （桂科AB22035019）
桂林市创新平台与人才计划(20210102-3) （20210102-3）
国家自然科学基金项目(82060764,32060108) （82060764,32060108）
