遵义医科大学学报2024，Vol.47Issue(8)：789-794,800,7.
2型糖尿病患者发生糖尿病肾脏病风险预测模型的建立和验证
Establishment and validation of the risk prediction model for diabetic kidney disease in patients with type 2 diabetes
摘要
Abstract
Objective To analyze the risk factors related to diabetic kidney disease(DKD)in type 2 diabetes(T2DM)patients and develop a risk prediction model.Methods Retrospective analysis of T2DM patient data from the Geriatric Hospital of Nanjing Medical University from November 2005 to June 2022.Patients were divid-ed into DKD and Non-DKD groups.Baseline data were compared,and univariate Cox analysis was conducted.Significant variables and key factors from literature were used in multivariate Cox regression to develop the mod-el,represented as a nomogram and internally validated.Results Of the 600 T2DM patients,203(33.8％)de-veloped DKD.Multivariate Cox analysis identified female,low eGFR level,high UACR level,low HDL-C level,and increased postprandial glucose(PPG)were independent risk factors for DKD.A model based on Cox with the above factors were established and showed good prediction ability,with AUCs of 0.71(training)and 0.77(validation),respectively.Conclusion This study identified independent risk factors for DKD in T2DM patients and established a reliable risk prediction model,which provided a reference for clinical practice.关键词
2型糖尿病/糖尿病肾脏病/风险因素/风险预测模型Key words
type 2 diabetes mellitus/diabetic kidney disease/risk factors/risk prediction model分类
医药卫生引用本文复制引用
朱翔宇,俞匀,唐伟..2型糖尿病患者发生糖尿病肾脏病风险预测模型的建立和验证[J].遵义医科大学学报,2024,47(8):789-794,800,7.基金项目
江苏省重点研发计划社会发展项目(NO:BE2023774) （NO:BE2023774）
江苏省卫健委老年医学临床技术应用研究项目(NO:LR2022005). （NO:LR2022005）
