遵义医科大学学报2024，Vol.47Issue(8)：795-800,6.
血清泛素羧基末端水解酶L1联合APACHE Ⅱ评分对一氧化碳中毒患者认知功能障碍的预测价值
Predictive value of serum ubiquitin C-terminal hydrolase L1 combined with A-PACHE Ⅱ score for cognitive impairment in patients with carbon monoxide poisoning
摘要
Abstract
Objective To investigate the predictive value of serum ubiquitin C-terminal hydrolase L1(UCH-L1)combined with acute physiology and chronic health assessment Ⅱ(APACHE Ⅱ)score for cognitive impairment in patients with carbon monoxide(CO)poisoning.Methods A total of 135 patients with acute CO poisoning di-agnosed in our hospital from July 2020 to July 2023 were selected as the objects of this study.According to mini-mental state examination,The MMSE score of 135 patients with acute CO poisoning was divided into cognitive impairment(n=28)and accessibility(n=107)groups.Serum UCH-L1 level was detected by ELISA and the severity of the disease was assessed by APACHE Ⅱ score within 24 hours of admission.Clinical data and UCH-L1 and APACHE Ⅱ scores were compared between the two groups.The correlation between serum UCH-L1 level and APACHE Ⅱ score was analyzed by Spearson test.Multivariate Logistic regression analysis was used to ex-plore the risk factors of cognitive dysfunction in patients with acute CO poisoning.The predictive value of UCH-L1,APACHE Ⅱ score and UCH-L1 combined APACHE Ⅱ score on cognitive dysfunction in patients with acute CO poisoning was evaluated by receiver operating characteristic(ROC)curve.Results Univariate analysis showed that APACHE Ⅱ score,blood lactic acid,white blood cell count and UCH-L1 level in the cognitive dys-function group were significantly higher than those in the barrier-free group(P＜0.05).UCH-L1 level was posi-tively correlated with APACHE Ⅱ score,blood lactic acid and white blood cell count(r values were 0.565,0.428 and 0.403,respectively,P＜0.05).Multivariate Logistic regression analysis showed:high APACHE Ⅱscore(OR=2.512,95％CI:1.582-3.989),high blood lactic acid(OR=2.145,95％CI:1.311-3.508),high white blood cell count(OR=1.835,95％CI:1.054-3.195),high UCH-L1 level(OR=2.898,95％CI:1.727-4.862)were risk factors for cognitive impairment in patients with acute CO poisoning(P＜0.05).The AUC of UCH-L1 and APACHE Ⅱ scores for predicting cognitive dysfunction in patients with acute CO poi-soning were 0.798(95％CI:0.712-0.836)and 0.749(95％CI:0.632-0.798),respectively.And the AUC predicted by UCH-L1 combined APACHE Ⅱ score was 0.844(95％CI:0.775-0.873).Conclusion Both UCH-L1 and APACHE Ⅱ scores were highly expressed in patients with acute CO poisoning with cognitive dys-function,which could be used as important indicators to predict whether patients with acute CO poisoning had cognitive dysfunction.Moreover,the combined detection had higher sensitivity and specificity,with better pre-diction efficiency.关键词
一氧化碳中毒/泛素羧基末端水解酶L1/急性生理和慢性健康评估/认知功能障碍Key words
carbon monoxide poisoning/ubiquitin c-terminal hydrolase 11/acute physiology and chronic health assessment/cognitive impairment分类
医药卫生引用本文复制引用
骆图南,刘洋,朱浩轩,景少巍,王艳秋,马遥,张莉,罗昕,欧阳晓春..血清泛素羧基末端水解酶L1联合APACHE Ⅱ评分对一氧化碳中毒患者认知功能障碍的预测价值[J].遵义医科大学学报,2024,47(8):795-800,6.基金项目
江西省卫生健康委科技计划项目(NO:202211376). （NO:202211376）
