组织工程与重建外科杂志2024，Vol.20Issue(4)：411-415,5.DOI:10.3969/j.issn.1673-0364.2024.04.003
自体表皮细胞悬液与网状自体刃厚皮移植联合治疗深Ⅱ度烧伤创面的临床研究
Clinical study on the combined application of autologous epidermal cell suspension and meshed autologous split thickness skin graft in the treatment of deep partial thickness burns
摘要
Abstract
Objective To evaluate the effect of autologous epidermal cell suspension combined with mesh skin graft in deep Ⅱ-degree burn wounds.Methods Patients with deep partial thickness burns were selected as the research subjects and randomly divided into two groups,control group and experimental group,according to the random table method.Control group received split-thickness mesh skin graft(n=8),and experimental group received autologous epidermal cell suspension combined with split-thickness mesh skin graft(n=8).The epidermal cell suspension was prepared from autologous donor skin by cell separator.The wound healing time,wound healing rate on first week after treatment,and scar score(Vancouver scale)on 8th week after surgery were statistically analyzed in the two groups.At the same time,the concentration and viability of epidermal cells in the cell suspension were detected.Results The healing time of experimental group was(10.2±0.3)days,compared with(12.1±0.6)days in control group(P＜0.05).The healing rates of control group and experimental group were 76.97％±10.68％ vs.94.85％±10.01％ (P＜0.05)one week after treatment,and the Vancouver scar scores of control group and experimental group were 6.13±3.44 vs.2.92±1.07(P＜0.05)at 8 weeks after surgery.The concentration of cell suspension was(1.77±0.11)×106 cells per cm² skin sample,and the cell viability was 87.85％±4％ .Conclusion This study preliminarily confirmed that autologous epidermal cell suspension combined with mesh skin transplantation in the treatment of deep partial thickness burns can promote skin grafting healing time,reduce donor area,and improve postoperative scar hyperplasia.关键词
烧伤/植皮/自体皮肤细胞悬液Key words
Burns/Skin grafting/Autologous epidermal cell suspension分类
医药卫生引用本文复制引用
杨惠忠,徐正鹏,原博,余天漪,刘琰,喜雯婧,乔亮..自体表皮细胞悬液与网状自体刃厚皮移植联合治疗深Ⅱ度烧伤创面的临床研究[J].组织工程与重建外科杂志,2024,20(4):411-415,5.基金项目
中央高校基本科研业务费专项资金资助(YG2022QN048). （YG2022QN048）
